Circulating adrenocorticotropic hormone (ACTH) and cortisol concentrations in normal, appropriate-for-gestational-age newborns versus those with sepsis and respiratory distress: cortisol response to low-dose and standard-dose ACTH tests
| Autor: | Hala AlRimawy, Ibrahim S. Nasr, Mohamed S.M Hamido, Ashraf T Soliman, Khaled H Taman, Mohamed Rizk |
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| Rok vydání: | 2004 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Hydrocortisone Endocrinology Diabetes and Metabolism Adrenocorticotropic hormone Sepsis Basal (phylogenetics) Endocrinology Adrenocorticotropic Hormone Reference Values Internal medicine medicine Humans Prospective Studies Leukocytosis Respiratory Distress Syndrome Newborn Dose-Response Relationship Drug Respiratory distress business.industry Infant Newborn Gestational age Radioimmunoassay medicine.disease Female medicine.symptom business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Metabolism. 53:209-214 |
| ISSN: | 0026-0495 |
| Popis: | In this crossover study, we compared the peak responses of cortisol to low-dose (1 microg/1.73 m(2)) and standard-dose (250 microg/1.73 m(2)) adrenocorticotropic hormone (ACTH) stimulation tests in 90 full-term newborns (37 to 42 weeks gestational age, birthweight > 2,500 g, aged 4 to 7 days): 30 with sepsis syndrome, 30 with respiratory distress (RD) and 30 normal infants. Basal cortisol and ACTH were measured in a fasting venous sample. Serum cortisol concentrations were measured 30 minutes after low-dose ACTH and 60 minutes after standard-dose ACTH by radioimmunoassay (RIA). The mean basal circulating cortisol concentration and peak cortisol responses to low-dose and standard-dose ACTH tests were higher in stressed infants with sepsis and RD compared to normal. Basal but not ACTH-stimulated cortisol concentrations were significantly higher in newborns with sepsis versus those with RD. Circulating cortisol concentrations after the low-dose ACTH test were correlated significantly with those obtained after the standard-dose ACTH test (r = 0.814, P |
| Databáze: | OpenAIRE |
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