Tamoxifen Prevents Bone Loss in Castrated Male Mice
| Autor: | P D Broulik |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_specialty Bone density medicine.drug_class Endocrinology Diabetes and Metabolism Clinical Biochemistry Mice Inbred Strains Biochemistry Mice chemistry.chemical_compound Endocrinology Bone Density Internal medicine Animals Medicine Femur skin and connective tissue diseases Testosterone Bone mineral business.industry Biochemistry (medical) Estrogen Antagonists Organ Size General Medicine Androgen Bone Diseases Metabolic Disease Models Animal Tamoxifen Castration medicine.anatomical_structure chemistry Selective estrogen receptor modulator Cortical bone business Orchiectomy medicine.drug |
| Zdroj: | Hormone and Metabolic Research. 32:181-184 |
| ISSN: | 1439-4286 0018-5043 |
| DOI: | 10.1055/s-2007-978618 |
| Popis: | The selective estrogen receptor modulator tamoxifen was administered to intact and castrated male mice, and its effects on tibial bones and circulatory calcium, phosphate and testosterone were compared with controls and castrated animals. Tamoxifen in a dose used in humans for treatment of breast cancer decreased the weight of seminal vesicles, an organ which is highly sensitive to the androgenic effect, decreased the concentration of testosterone, but did not have any negative effect on bone density or mineral content in intact mice. When castrated mice with extraordinarily low concentrations of testosterone and weights of seminal vesicles were treated with tamoxifen, the changes in bone density and bone mineral resulting from castration were not only entirely prevented, but increased above the values of intact mice. At the same time, cortical bone was lost in orchidectomized mice, and this decrease in cortical thickness of femur was completely prevented by tamoxifen treatment. Pharmacological therapy with estrogen agonist on bone, tamoxifen in androgen deficient adult male mice prevents bone loss. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|