Effect of Polysaccharide from Cordyceps militaris (Ascomycetes) on Physical Fatigue Induced by Forced Swimming
| Autor: | Yan-Feng Xu |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Animal Experimentation
Male Serum Applied Microbiology and Biotechnology Superoxide dismutase Mice chemistry.chemical_compound 0404 agricultural biotechnology Polysaccharides Drug Discovery Cordyceps militaris Animals Food science Fatigue Swimming Pharmacology Cordyceps Glycogen biology Traditional medicine 04 agricultural and veterinary sciences Malondialdehyde biology.organism_classification 040401 food science Lactic acid chemistry Catalase biology.protein Female Creatine kinase |
| Zdroj: | International Journal of Medicinal Mushrooms. 18:1083-1092 |
| ISSN: | 1521-9437 |
| Popis: | Cordyceps militaris is the one of the most important medicinal mushrooms, widely used in East Asian countries. Polysaccharide is considered to be the principal active component in C. militaris and has a wide range of biological and pharmacological properties. This study was undertaken to investigate the effect of polysaccharide from C. militaris (PCM) on physical fatigue induced in animals through a forced swimming test. The mice were divided into 4 groups receiving 28 days' treatment with drinking water (exercise control) or low-, medium-, and high-dose PCM (40, 80, and 160 mg/kg/day, respectively). After 28 days, the mice were subjected to the forced swimming test; the exhaustive swimming time was measured and fatigue-related biochemical parameters, including serum lactic acid, urea nitrogen, creatine kinase, alanine aminotransferase, aspartate aminotransferase, superoxide dismutase, glutathi- one peroxidase, catalase, malondialdehyde, liver glycogen, and muscle glycogen, were analyzed. The results showed that PCM could significantly prolong the exhaustive swimming time of mice; decrease concentrations of serum lactic acid, urea nitrogen, creatine kinase, aspartate aminotransferase, alanine aminotransferase, and malondialdehyde; and increase liver and muscle glycogen contents and the concentrations of serum superoxide dismutase, glutathione per- oxidase, and catalase. The data suggest that PCM has an antifatigue effect, and it might become a new functional food or medicine for fatigue resistance. |
| Databáze: | OpenAIRE |
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