C-reactive protein predicts future arterial and cardiovascular events in patients with symptomatic peripheral arterial disease
| Autor: | Annette Høgh, Martin R. Jacobsen, Lars Østergaard, Jes S. Lindholt, Jette Bang Joensen |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Time Factors medicine.medical_treatment Revascularization Risk Assessment Sensitivity and Specificity Severity of Illness Index Predictive Value of Tests Internal medicine medicine Humans Myocardial infarction Prospective Studies Stroke Aged Peripheral Vascular Diseases biology business.industry Vascular disease C-reactive protein Reproducibility of Results General Medicine Middle Aged medicine.disease Thrombosis Peripheral Surgery Up-Regulation C-Reactive Protein Amputation ROC Curve Cardiovascular Diseases Cardiology biology.protein Disease Progression Female Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | Høgh, A L, Joensen, J, Lindholt, J S, Jakobsen, M R & Østergaard, L 2008, ' C-reactive protein predicts future arterial and cardiovascular events in patients with symptomatic peripheral arterial disease. ', Vascular and Endovascular Surgery, vol. 42, no. 4, pp. 341-7 . https://doi.org/10.1177/1538574408316138 |
| ISSN: | 1538-5744 |
| DOI: | 10.1177/1538574408316138 |
| Popis: | Udgivelsesdato: null-null High-sensitivity C-reactive protein is associated with increased risk of cardiovascular events. Consequently, the predictive value of this protein in patients with symptomatic peripheral arterial disease was examined. In all, 452 patients with symptomatic peripheral arterial disease had high-sensitivity C-reactive protein measured at baseline (mean follow-up = 2.1 +/- 1.4 years). Events were defined as primary (death, amputation, or peripheral revascularization) or secondary (lower limb thrombosis, myocardial infarction, or stroke).The level of high-sensitivity C-reactive protein was significantly higher among those dying (P = .04), those who needed amputation (P = .01), and those developing an overall secondary endpoint (P = .02). By receiver-operating characteristic curve analysis, the optimal cutoff point was constantly approximately 10 to 20 mg/L with a sensitivity and specificity of 56% to 63% and 54% to 56%, respectively. Baseline levels of high-sensitivity C-reactive protein are associated with future arterial events in symptomatic peripheral arterial disease patients but cannot stand alone as a predictive tool. |
| Databáze: | OpenAIRE |
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