A Rare Case of Angioimmunoblastic T-Cell Lymphoma with Epstein-Barr Virus-Negative Reed-Sternberg-Like B-Cells, Chylous Ascites, and Chylothorax
| Autor: | Arne W J H Dielis, Mathijs Willemsen, Ad Koster, Iryna V Samarska, Arienne M van Marion |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Pathology
medicine.medical_specialty Angioimmunoblastic T-cell lymphoma Hepatosplenomegaly Case Report medicine.disease_cause 03 medical and health sciences 0302 clinical medicine immune system diseases Chylous ascites hemic and lymphatic diseases medicine business.industry lcsh:RC633-647.5 Chylothorax General Medicine lcsh:Diseases of the blood and blood-forming organs medicine.disease Epstein–Barr virus Lymphoma B symptoms 030220 oncology & carcinogenesis medicine.symptom business Generalized lymphadenopathy 030215 immunology |
| Zdroj: | Case Reports in Hematology, Vol 2017 (2017) Case Reports in Hematology |
| ISSN: | 2090-6579 2090-6560 |
| Popis: | Angioimmunoblastic T-cell lymphoma is a rare non-Hodgkin lymphoma with dismal prognosis. The median age of presentation ranges from 62 to 69 years with generalized lymphadenopathy, B symptoms, and hepatosplenomegaly as the most prevalent symptoms. The combination of B-cell and T-cell proliferations is common in AITL and the B-cell component may resemble Reed-Sternberg-like B-cells. Epstein-Barr virus is estimated to be present in 80–95% of AITL biopsies. Only a handful of EBV-negative AITL cases with EBV-negative RS-like B-cells have been reported over the last decade. We present a rare case of EBV-negative AITL with chylous ascites and chylothorax. Microscopic and immunohistochemical analysis revealed the presence of EBV-negative Reed-Sternberg-like B-cells in the tumor. |
| Databáze: | OpenAIRE |
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