Microbiological transformation of cannabinoids
| Autor: | R. A. Archer, David S. Fukuda, B. J. Abbott |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Stereochemistry
medicine.medical_treatment Cyclohexene Ketone formation Hydroxylation Ring (chemistry) Cellular and Molecular Neuroscience chemistry.chemical_compound Actinomycetales medicine Side chain Dronabinol Molecular Biology Biotransformation Soil Microbiology Pharmacology Bacteria Cannabinoids Chemistry Fungi Aromatization Cell Biology Transformation (genetics) Molecular Medicine Cannabinoid Oxidation-Reduction |
| Zdroj: | Experientia. 33:718-720 |
| ISSN: | 1420-9071 0014-4754 |
| DOI: | 10.1007/bf01944147 |
| Popis: | Microorganisms were screened for their ability to modify 2 synthetic cannabinoid substrates (I and II). Structure analyses revealed that microorganisms transformed the substrates by (a) primary oxidation of the side chain, beta-oxidation of the side chain, ketone formation on the side chain or cyclohexene ring, (b) secondary hydroxylation on the side chain, (c) aromatization of the cyclohexene ring, and (d) tertiary hydroxylation at the b/c ring juncture. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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