ERYTHROCYTE GLUTATHIONE PEROXIDASE DEFICIENCY IN MULTIPLE SCLEROSIS
| Autor: | Jørgen Clausen, Gunde Egeskov Jensen, V. K. S. Shukla |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Erythrocytes Multiple Sclerosis chemistry.chemical_element Biology Pathogenesis Selenium Internal medicine medicine GLUTATHIONE PEROXIDASE DEFICIENCY Humans Family history chemistry.chemical_classification Glutathione Peroxidase Multiple sclerosis Glutathione peroxidase General Medicine Middle Aged medicine.disease Glutathione peroxidase activity United States Endocrinology Peroxidases Neurology chemistry Female Neurology (clinical) Hemoglobin |
| Zdroj: | Acta Neurologica Scandinavica. 56:542-550 |
| ISSN: | 1600-0404 0001-6314 |
| Popis: | The present study demonstrates a significant decrease in glutathione peroxidase activity in erythrocytes of 24 patients with multiple sclerosis (MS) when the data are expressed as enzymic units per mg hemoglobin and compared to data from normal controls without known family history of demyclinating diseases. Since selenium is an essential part of glutathione peroxidase, this study also compares the topographic differences in selenium availability (expressed as selenium content of forage) withage) iwth the prevalence and death rates of MS in the USA. The comparison cannot exclude the possibility of a relationship between low selenium content and high prevalence as MS. The data are discussed in relationship to current theories on the pathogenesis of MS. |
| Databáze: | OpenAIRE |
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