Persistent organic pollutant exposure and celiac disease: A pilot study
| Autor: | Kristen Thomas, Kurunthachalam Kannan, Leonardo Trasande, Abigail Gaylord, Mengling Liu, Sunmi Lee, Jeremiah Levine |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Dichlorodiphenyl Dichloroethylene Population Physiology Pilot Projects Disease 010501 environmental sciences 01 natural sciences Biochemistry Serology 03 medical and health sciences 0302 clinical medicine Blood serum Halogenated Diphenyl Ethers Genetic predisposition Humans Medicine Outpatient clinic 030212 general & internal medicine Child education 0105 earth and related environmental sciences General Environmental Science Autoimmune disease education.field_of_study business.industry Odds ratio medicine.disease Polychlorinated Biphenyls Celiac Disease Environmental Pollutants Female business |
| Zdroj: | Environmental Research. 186:109439 |
| ISSN: | 0013-9351 |
| DOI: | 10.1016/j.envres.2020.109439 |
| Popis: | Celiac disease affects approximately 1% of the population worldwide. Little is known about environmental factors that may modulate risk in genetically susceptible populations. Persistent organic pollutants (POPs) are known endocrine disruptors and, given the interplay between the endocrine and immune systems, are plausible contributors to celiac disease. The current study aims to elucidate the association between POPs and celiac disease. We conducted a single-site pilot study of 88 patients recruited from NYU Langone's Hassenfeld Children's Hospital outpatient clinic, 30 of which were subsequently diagnosed with celiac disease using standard serology and duodenal biopsy examination. Polybrominated diphenyl ether (PBDEs), perfluoroalkyl substances (PFASs), and p,p’-dichlorodiphenyldichloroethylene (DDE) and HLA-DQ genotype category were measured in blood serum and whole blood, respectively. Multivariable logistic regressions were used to obtain odds ratios for celiac disease associated with serum POP concentrations. Controlling for sex, race, age, BMI, and genetic susceptibility score, patients with higher serum DDE concentrations had 2-fold higher odds of celiac disease (95% CI: 1.08, 3.84). After stratifying by sex, we found higher odds of celiac disease in females with serum concentrations of DDE (OR = 13.0, 95% CI = 1.54, 110), PFOS (OR = 12.8, 95% CI = 1.17, 141), perfluorooctanoic acid (OR = 20.6, 95% CI = 1.13, 375) and in males with serum BDE153, a PBDE congener (OR = 2.28, 95% CI = 1.01, 5.18). This is the first study to report on celiac disease with POP exposure in children. These findings raise further questions of how environmental chemicals may affect autoimmunity in genetically susceptible individuals. |
| Databáze: | OpenAIRE |
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