Beneficial effects of hydrocortisone and papaverine on a model of pulmonary embolism induced by autologous blood clots in isolated and perfused rabbit lungs
| Autor: | Ignacio Castro, Greenmy R. Centeno, Juan C. Caraballo, Roberto Sánchez de León, Alejandro A. Pezzulo, Jeydith Gutierrez, Humberto E. Trejo, Daniela Urich |
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| Rok vydání: | 2007 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Pathology Hydrocortisone Vasodilator Agents Anti-Inflammatory Agents Hemodynamics Pulmonary Edema Vasodilation In Vitro Techniques Papaverine Internal medicine medicine.artery medicine Animals Prospective Studies business.industry Pulmonary edema medicine.disease Pathophysiology Pulmonary embolism Disease Models Animal Vasoconstriction Pulmonary artery Respiratory Mechanics Cardiology Rabbits medicine.symptom Pulmonary Embolism business medicine.drug |
| Zdroj: | Respirology. 12:799-806 |
| ISSN: | 1440-1843 1323-7799 |
| Popis: | Background and objective: Mechanical obstruction has been considered the prime determinant of haemodynamic changes after pulmonary embolism (PE); however, the function of vasoconstrictive and inflammatory mediators in the physiopathology of this disease is unclear. The aim of this investigation was to study the effect of an anti-inflammatory and a vasodilator in a setting of induced PE. Methods: A prospective, laboratory study was undertaken using 30 New Zealand white rabbits. A model of isolated and perfused rabbit lungs was used; PE was induced using autologous blood clots. Six study groups were established (each n = 5): PE without any drug (PG); PE + papaverine (PpG); PE + hydrocortisone (HG); PE in West's Zone III (ZIIIG); PE using acellular perfusate (AG) and PE using acellular perfusate + papaverine (APpG). The pulmonary artery pressure (PAP) and fluid filtration rate (FFR) were continuously measured during the experiments. Results: Increases in PAP and oedema formation were observed in the PG after embolization. The PpG and the APpG showed neither oedema nor significant PAP increases. The HG group developed less oedema and less increase in PAP compared with the PG. The ZIIIG developed oedema the fastest. The AG developed less oedema and increases in PAP compared with the PG. Conclusion: These findings suggest that vasoconstriction and inflammatory mediators play an important role in the physiopathology of PE, as neither PAP increases nor oedema were observed in the PpG and a reduction of oedema and PAP was seen in the HG group. The decrease in oedema and PAP in the acellular group strongly suggests a key role of circulating blood cells. |
| Databáze: | OpenAIRE |
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