Antibiotics-induced oxidative stress
| Autor: | Christiane Guguen-Guillouzo, André Guillouzo |
|---|---|
| Přispěvatelé: | Nutrition, Métabolismes et Cancer (NuMeCan), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), European Commission, Jonchère, Laurent, Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Programmed cell death [SDV]Life Sciences [q-bio] Oxidative phosphorylation 010501 environmental sciences Mitochondrion Penicillinase-resistant antibiotics Toxicology medicine.disease_cause 01 natural sciences antibiotics 03 medical and health sciences Hsp27 medicine 0105 earth and related environmental sciences trovafloxacin chemistry.chemical_classification flucloxacillin Reactive oxygen species Cholestasis biology Heat shock proteins Endoplasmic reticulum 3. Good health Cell biology [SDV] Life Sciences [q-bio] [SDV.TOX] Life Sciences [q-bio]/Toxicology 030104 developmental biology chemistry Oxidative stress erythromycin [SDV.TOX]Life Sciences [q-bio]/Toxicology Toxicity biology.protein Endoplasmic reticulum stress Mitochondrial dysfunction drug-induced liver injury |
| Zdroj: | Current Opinion in Toxicology Current Opinion in Toxicology, 2020, 20-21, pp.23-28. ⟨10.1016/j.cotox.2020.03.004⟩ Current Opinion in Toxicology, [Amsterdam] : Elsevier B.V., [2016]-, 2020, 20-21, pp.23-28. ⟨10.1016/j.cotox.2020.03.004⟩ |
| ISSN: | 2468-2020 |
| DOI: | 10.1016/j.cotox.2020.03.004⟩ |
| Popis: | This review comes from a themed issue on Oxidative Toxicology; Edited by Yvonne Will, Moorthy Bhagavatula, Martin van den Berg and Jose Manautou; International audience; Around one hundred drugs of our modern pharmacopeia are efficacious and useable as antibiotics (ATBs) in medicine; they are used to kill or block growth of bacteria. Bactericidal ATBs can induce a common oxidative damage pathway, leading to the production of reactive oxygen species and cell death. ATBs can also damage various mammalian cell types and tissues but mechanisms of action remain relatively unclear. Both bactericidal and bacteriostatic ATBs can target mitochondria but only the former usually induce mitochondrial dysfunction and oxidative stress at clinically relevant doses. Human liver is a major target of ATBs of which toxicity is mostly idiosyncratic. Interestingly, β-lactam penicillinase-resistant ATBs, which are known to cause mostly immune reactions in patients, induce an early endoplasmic reticulum stress in in vitro human hepatocytes at low concentrations; this stress is inhibited by activation of the HSP27 protein which acts as a protective response associated with occurrence of cholestatic features. In this review, we analyze the importance of oxidative and endoplasmic reticulum stress in cellular damage induced by ATBs, especially in hepatocytes and highlight specific cellular protection mechanisms associated with penicillinase-resistant ATB treatments. |
| Databáze: | OpenAIRE |
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