Vitamin A and retinoic acid stimulate within minutes cAMP release and growth hormone secretion in human pituitary cells
| Autor: | F. Peillon, D. Evain-Brion, P. Pagesy, J. Y. Li, C. Djakoure, D Porquet, Jean Guibourdenche |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty Pituitary gland Time Factors Somatotropic cell Endocrinology Diabetes and Metabolism Clinical Biochemistry Retinoic acid Tretinoin Stimulation Biology Biochemistry chemistry.chemical_compound Endocrinology Internal medicine Cyclic AMP Tumor Cells Cultured medicine Humans Secretion Vitamin A Biochemistry (medical) Middle Aged Growth hormone secretion Perfusion Somatropin medicine.anatomical_structure chemistry Growth Hormone Pituitary Gland Female medicine.drug |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 81:3123-3126 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem.81.8.8768885 |
| Popis: | In order to gain a better understanding on the possible role of vitamin A (VA) and retinoic acid (RA) on human growth hormone (GH) secretion, we used the physiological model of pituitary cells perifusion. In perifused cells from pituitary somatotropic adenomas, RA induced within minutes a peak of GH secretion. This effect was dose dependent, maximal effect being observed with 100 nM. The GH release was associated with a discharge of cAMP delayed by 4 to 8 minutes relative to the GH surge. Similar results were obtained after VA stimulation. Our observations provide the first evidence of an action of VA and RA on cAMP production. They suggest a role of RA and VA in the regulation of human GH secretion via the cAMP dependent pathway. |
| Databáze: | OpenAIRE |
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