Predictors of Poor Response and Adverse Events Following Botulinum Toxin-A for Refractory Idiopathic Overactive Bladder
| Autor: | Arun Sahai, Luke Stroman, Sachin Malde, Eskinder Solomon, Mohammad Muneeb Abrar |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Urology Urinary system Urinary Bladder 030232 urology & nephrology Single Center Injections Intramuscular 03 medical and health sciences Sex Factors 0302 clinical medicine Surveys and Questionnaires Internal medicine medicine Humans Intermittent Urethral Catheterization Botulinum Toxins Type A Adverse effect Retrospective Studies Urinary bladder Urinary Bladder Overactive Genitourinary system business.industry Retrospective cohort study Middle Aged Prognosis Urination Disorders medicine.disease Self Care Administration Intravesical Treatment Outcome medicine.anatomical_structure Neuromuscular Agents Overactive bladder 030220 oncology & carcinogenesis Urinary Tract Infections Cohort Female business |
| Zdroj: | Urology. 135:32-37 |
| ISSN: | 0090-4295 |
| DOI: | 10.1016/j.urology.2019.08.054 |
| Popis: | Objective To ascertain whether a poor response and adverse events (voiding dysfunction and urinary tract infection) were predictable for first time botulinum toxin-A (BTX-A) injections in a patient cohort of refractory idiopathic overactive bladder with detrusor overactivity. Methods Patients who received BTX-A injections for the first time between the dates of March 2004-August 2017 were analyzed in this single center study. Urogenital Distress Inventory short form (UDI-6) questionnaires were collected both preinjection and postinjection prospectively. A poor response was defined as a decrease of less than 16.7 on the UDI-6 questionnaire. Additional information was gathered from patient records in a retrospective fashion. Predictors of poor response, voiding dysfunction, and UTI were analyzed with multivariate logistic regression analysis. Results Seventy-four patients were analyzed. The only predictor of poor response was male gender (OR, 5.45; 95% CI 1.83-16.47; P = .002). Lower maximum urinary flow rates (OR, 0.91; 95% CI, 0.83-0.99; P = .023), male gender (OR, 5.14; 95% CI 1.41-18.72; P = .013), and hysterectomy in females (OR, 4.55; 95% CI, 1.09-18.87; P = .038) were predictors of clean intermittent self catheterisation (CISC). There was an increased risk of UTIs in patients who performed CISC (OR, 5.26; 95% CI 1.38-20.0; P = .015). Conclusion Male gender was associated with a poor response to BTX-A injections and increased risk of CISC. Lower maximum urinary flow rates and women with hysterectomies were at increased risk of requiring CISC postinjection. Performing CISC was associated with increased risk of UTI. These factors could be helpful when counselling or selecting patients. |
| Databáze: | OpenAIRE |
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