Memory impairment induced by different types of prolonged stress is dependent on the phase of the estrous cycle in female rats
| Autor: | Alessandra Mussi Ribeiro, Regina H. Silva, Deborah Suchecki, Ezequiel Batista do Nascimento, Aline L. Dierschnabel, André de Macêdo Medeiros |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Estrous Cycle Endogeny 03 medical and health sciences Behavioral Neuroscience chemistry.chemical_compound 0302 clinical medicine Endocrinology Corticosterone Internal medicine medicine Animals Memory impairment Rats Wistar Social isolation Estrous cycle Memory Disorders Estradiol Endocrine and Autonomic Systems business.industry Cognition Rats 030227 psychiatry Disease Models Animal chemistry Estrogen Female medicine.symptom business Stress Psychological 030217 neurology & neurosurgery Hormone |
| Zdroj: | Hormones and Behavior. 115:104563 |
| ISSN: | 0018-506X |
| Popis: | A growing body of evidence demonstrates that estrogen and corticosterone (CORT) impact on cognition and emotion. On the one hand, ovarian hormones may have beneficial effects on several neurophysiological processes, including memory. On the other hand, chronic exposure to stressful conditions has negative effects on brain structures related to learning and memory. In the present study, we used the plus-maze discriminative avoidance task (PMDAT) to evaluate the influence of endogenous variations of sex hormones and exposure to different types of prolonged stressors on learning, memory, anxiety-like behavior and locomotion. Female Wistar rats were submitted to seven consecutive days of restraint stress (4 h/day), overcrowding (18 h/day) or social isolation (18 h/day) and tested in different phases of the estrous cycle. The main results showed that: (1) neither stress conditions nor estrous cycle modified PMDAT acquisition; (2) restraint stress and social isolation induced memory impairments; (3) this impairment was observed particularly in females in metestrus/diestrus; (4) stressed females in estrus displayed less risk assessment behavior, suggesting reduced anxiety-like behavior; (5) restraint stress and social isolation, but not overcrowding, elevated corticosterone levels. Taken together, our findings suggest that the phase of the estrous cycle is an important modulatory factor of the cognitive processing disrupted by stress in female rats. Negative effects were observed in metestrus/diestrus, indicating that the peak of sex hormones may protect females against stress-induced memory impairment. |
| Databáze: | OpenAIRE |
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