Synthesis, Characterization and Antimicrobial Activity of Certain Novel Aryl Hydrazone Pyrazoline-5-Ones Containing Thiazole Moiety
| Autor: | Reddy, Maliki Reddy Dastagiri, Prasad, Aluru Raghavendra Guru, Spoorthy, Yadati Narasimha, Ravindranath, Lakshmana Rao Krishna Rao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Advanced Pharmaceutical Bulletin, Vol 3, Iss 1, Pp 153-159 (2013) |
| ISSN: | 2251-7308 2228-5881 |
| Popis: | Purpose: The aim of this article is to synthesize, characterize and evaluate the antimicrobial activity of certain novel 3-methyl-5-oxo-4-(phenyl hydrazono)-4,5-dihydro-pyrazol-1-yl]-acetic acid N|-(4-substituted thiazol-2-yl)-hydrazides. Methods: The synthesized compounds were characterized by elemental analysis and IR, NMR and mass spectral data. The antimicrobial activity of novel compounds was evaluated by broth dilution method. Results: XVe, XVf and XVg have shown better antibacterial activity than other compounds of the series. XVa, XVc, XVd and XVe have shown better antifungal activity than the other compounds of the series. Conclusion: All compounds were found to exhibit fair degree of antimicrobial activity. Advanced Pharmaceutical Bulletin; eISSN 2251-7308 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|