DIAGNOSTIC VALUE OF SERUM THYROXINE AND FREE THYROXINE INDEX
| Autor: | R. Ruutu, K. Liewendahl, B.‐A. Lamberg |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
endocrine system diseases chemistry.chemical_element Modified method Thyroid Function Tests Iodine Binding Competitive Hyperthyroidism Iodine Radioisotopes Triiodothyronine uptake Serum thyroxine Hypothyroidism Internal medicine Methods Internal Medicine medicine Humans business.industry Free thyroxine index Thyroid Serum samples Thyroxine medicine.anatomical_structure Endocrinology chemistry Sephadex Triiodothyronine business Goiter Nodular |
| Zdroj: | Acta Medica Scandinavica. 194:341-348 |
| ISSN: | 0001-6101 |
| DOI: | 10.1111/j.0954-6820.1973.tb19456.x |
| Popis: | A modified method for determination of serum total thyroxine (T4) using competitive protein-binding is reported. This method proved particularly valuable when analysing a large number of serum samples. A clinical evaluation of T4 was performed in various thyroid disorders. T4 was found to be superior to serum protein-bound iodine (PBI) in hyperthyroidism, mainly because of frequently encountered spuriously increased PBI values. In hypothyroidism PBI proved to be more accurate than T4, and there were many patients with low-normal T4 values who benefited by administration of thyroid hormones. Three different free thyroxine indices were studied. One was similar to the original free thyroxine index, here abbreviated T8I, defined as the product of PBI and triiodothyronine uptake by Sephadex (T3U). Another free thyroxine index (FT4I) was calculated as the product of T4 and thyroxine uptake by Sephadex (T4U). The product of T4 and TaU was the third free thyroxine index (FT3I) studied. Of these indices T3I had the lowest diagnostic accuracy in both hyper- and hypothyroidism. FT4I and FT3I were of approximately equal value in hyper- and hypothyroidism. The clinical usefulness of both FT4I and FT3I was superior to that of T4 in all conditions studied. It is recommended that both of these free thyroxine indices are determined when mild hyper- or hypothyroidism is suspected. |
| Databáze: | OpenAIRE |
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