Relationship between heterogeneous changes in airway morphometry and lung resistance and elastance
| Autor: | Kenneth R. Lutchen, Heather L. Gillis |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Models
Anatomic Functional Residual Capacity Physiology Respiratory System Bronchi Respiratory physiology Biology Constriction Airway resistance Dogs Physiology (medical) medicine Animals Respiratory system Lung Airway Resistance Total Lung Capacity Anatomy respiratory system Elasticity respiratory tract diseases Trachea medicine.anatomical_structure Breathing Respiratory Physiological Phenomena Bronchoconstriction medicine.symptom Airway |
| Zdroj: | Journal of applied physiology (Bethesda, Md. : 1985). 83(4) |
| ISSN: | 8750-7587 |
| Popis: | Lutchen, Kenneth R., and Heather Gillis. Relationship between heterogeneous changes in airway morphometry and lung resistance and elastance. J. Appl. Physiol.83(4): 1192–1201, 1997.—We present a dog lung model to predict the relation between inhomogeneous changes in airway morphometry and lung resistance (Rl) and elastance (El) for frequencies surrounding typical breathing rates. The Rl and El were sensitive in distinct ways to two forms of peripheral constriction. First, when there is a large and homogeneous constriction, the Rl increases uniformly over the frequency range. The El is rather unaffected below 1 Hz but then increases with frequencies up to 5 Hz. This increase is caused by central airway wall shunting. Second, the Rl and El are extremely sensitive to mild inhomogeneous constriction in which a few highly constricted or nearly closed airways occur randomly throughout the periphery. This results in extreme increases in the levels and frequency dependence of Rland El but predominantly at typical breathing rates ( |
| Databáze: | OpenAIRE |
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