Hyperhomocyst(e)inemia and risk of ischemic stroke among young Asian adults
| Autor: | Nigel Choon Kiat Tan, Seang-Mei Saw, Narayanaswamy Venketasubramanian, Helen Tjoei-Lian Tjia |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Carotid Artery Diseases Male medicine.medical_specialty Hyperhomocysteinemia Adolescent Taiwan Comorbidity Risk Assessment Brain Ischemia Age Distribution Risk Factors Diabetes mellitus Internal medicine Medicine Humans Young adult Risk factor Sex Distribution Stroke Retrospective Studies Advanced and Specialized Nursing Vertebral Artery Dissection business.industry Case-control study Retrospective cohort study Cerebral Infarction Middle Aged medicine.disease Surgery Intracranial Embolism Female Neurology (clinical) Cardiology and Cardiovascular Medicine business |
| Zdroj: | Stroke. 33(8) |
| ISSN: | 1524-4628 |
| Popis: | Background and Purpose — Hyperhomocyst(e)inemia is emerging as a possible risk factor for stroke, possibly because of accelerated atherosclerosis. There are no previous publications evaluating homocyst(e)ine in young Asian ischemic stroke patients. We conducted a case-control study examining homocyst(e)ine, vitamin B 12 , and folate levels in young, first-ever Asian ischemic stroke patients. Methods — We prospectively recruited 109 consecutive young (12 , and folate were assayed. Stroke mechanisms were subtyped using TOAST study criteria. Results — Mean age was 43.8 (cases) and 43.1 (controls) years; 71.6% were male (cases and controls). Diabetes mellitus, hypertension, and hyperlipidemia were significantly more prevalent in cases. Mean fasting homocyst(e)ine levels were significantly higher in cases (13.7 μmol/L, 95% CI: 12.7 to 14.9) than controls (10.8 μmol/L, 95% CI: 9.9 to 11.8, P 12 levels were significantly lower in cases (299.5 pmol/L, 95% CI: 266.7 to 332.3) than controls (394.5 pmol/L, 95% CI: 357.9 to 431.0, P P P =0.001) for every 1 μmol/L increase in log homocyst(e)ine. Conclusions — Hyperhomocyst(e)inemia is an independent risk factor for ischemic strokes in young Asian adults. The relationship between increasing homocyst(e)ine and stroke risk is strong, graded, and significant. The association with large-artery strokes suggests that hyperhomocyst(e)inemia may increase stroke risk via a proatherogenic effect. |
| Databáze: | OpenAIRE |
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