1,3-Diaryltriazenes: a new class of anorectic agents
| Autor: | Bernard Loev, Kerry G. Stanley, David T. Hill, E. Macko, James P. McCafferty, Janice E. Karoglan Williams, P. J. Fowler, C. E. Berkoff, Christine B. Ladd |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Dextroamphetamine
Central nervous system Motor Activity Pharmacology Eating Structure-Activity Relationship chemistry.chemical_compound Dogs Appetite Depressants Fenfluramine Drug Discovery medicine Animals Triazene Saimiri Trifluoromethyl Dose-Response Relationship Drug Body Weight Drug administration Biological activity Drug Tolerance Anorectic Activity Rats medicine.anatomical_structure chemistry Molecular Medicine Triazenes Anorectic Agents |
| Zdroj: | Journal of Medicinal Chemistry. 26:865-869 |
| ISSN: | 1520-4804 0022-2623 |
| Popis: | A series of substituted 1,3-diaryltriazenes has been synthesized and tested for anorectic activity. Several members of the series were effective; one compound, 1,3-bis[2-cyano-5-(trifluoromethyl)phenyl]triazene, was particularly active, causing weight loss in rats, dogs, and squirrel monkeys. It was devoid of overt central nervous system activity, and compared to previously reported biologically active triazenes, it was relatively nontoxic up to 30 days of drug administration. |
| Databáze: | OpenAIRE |
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