Carcinoma-associated retinopathy in a young teenager with immature teratoma of the ovary

Autor: Valeria L. N. Fu, Daniel Kietz, Hannah L. Scanga, Kiran Turaka, Christin L. Sylvester, Ellen Mitchell, Lakshmanan Krishnamurti
Rok vydání: 2014
Předmět:
medicine.medical_specialty
Visual acuity
genetic structures
Adolescent
Color vision
Ovariectomy
Prednisolone
Visual Acuity
Antineoplastic Agents
Color Vision Defects
Fundus (eye)
Autoantigens
Methylprednisolone
Antibodies
Monoclonal
Murine-Derived
Ophthalmology
medicine
Electroretinography
Humans
Immunologic Factors
Fluorescein Angiography
Glucocorticoids
Autoantibodies
Ovarian Neoplasms
Arrestin
medicine.diagnostic_test
business.industry
Paraneoplastic Syndromes
Ocular
Teratoma
Immunoglobulins
Intravenous
Fluorescein angiography
medicine.disease
eye diseases
Surgery
Pediatrics
Perinatology and Child Health
Retinal pigment epithelial atrophy
Evoked Potentials
Visual
Immature teratoma
Drug Therapy
Combination
Female
sense organs
medicine.symptom
business
Rituximab
Tomography
Optical Coherence
Retinopathy
Zdroj: Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus. 18(4)
ISSN: 1528-3933
Popis: A 14-year-old African American girl presented with diminished vision in both eyes 1 week after undergoing an oophorectomy for a right ovarian mass. Systemic metastatic work-up was negative. Visual acuity was 20/40 in the right eye and 20/50 in the left eye. Slit-lamp biomicroscopy was unremarkable in both eyes. Fundus examination showed diffuse patchy areas of retinal pigment epithelial atrophy in the macula and peripheral retina bilaterally. Color vision had decreased in each eye. Electroretinography revealed nondetectable rod and cone responses. Both pattern and flash visual evoked potential (VEP) testing showed delayed latency in both eyes. She was treated with pulse intravenous methylprednisolone for 3 days along with intravenous immunoglobulins and rituximab, followed by systemic prednisolone and biweekly intravenous immunoglobulins and rituximab for 3 months. Antiretinal autoantibodies against 48-kDa (arrestin) and 64-kDa and 94-kDa proteins were positive, suggestive of carcinoma-associated retinopathy. After 3 months, visual acuity was 20/40 in each eye with improvement in color vision and VEP findings.
Databáze: OpenAIRE
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