Involvement of arachidonic acid cascade in working memory impairment induced by interleukin-1 beta
| Autor: | Tsuneyuki Yamamoto, Shigenori Watanabe, Yuji Matsumoto, Taku Yamaguchi |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Diclofenac Dorsal hippocampus Hippocampus Cellular and Molecular Neuroscience chemistry.chemical_compound Internal medicine medicine Animals Rats Wistar Prostaglandin E2 Beta (finance) Pharmacology Memory Disorders Arachidonic Acid biology Working memory Rats Endocrinology chemistry biology.protein Arachidonic acid Cyclooxygenase Interleukin-1 Signal Transduction medicine.drug |
| Zdroj: | Neuropharmacology. 46:1195-1200 |
| ISSN: | 0028-3908 |
| DOI: | 10.1016/j.neuropharm.2004.02.012 |
| Popis: | The aim of the present study is to clarify the possible relevance of the arachidonic acid cascade to working memory in rats, by using a three-panel runway apparatus. Interleukin-1 beta, injected bilaterally into the dorsal hippocampus at a dose of 100 ng/side, significantly impaired working memory, and this impairment was attenuated by pretreatment with 10 mg/kg (s.c.) of diclofenac, a cyclooxygenase inhibitor. Working memory was also impaired in rats administered a bilateral intrahippocampal injection of prostaglandin E2, in a dose-dependent manner at 0.01-1 microg/side. Furthermore, an injection of 100 ng/side of interleukin-1 beta significantly increased production of prostaglandin E2 (580 +/- 32 pg to 1142 +/- 101 pg/100 mg wet tissue) in the hippocampus. Taken together, these findings suggest that the activation of the arachidonic acid cascade was causative of the working memory impairment induced by interleukin-1 beta. |
| Databáze: | OpenAIRE |
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