Diacylglycerol (DAG) rich rice bran and sunflower oils modulate lipid profile and cardiovascular risk factors in Wistar rats
| Autor: | Vijayaraj Panneerselvam, A.G. Gopala Krishna, Maheswaraiah Anikisetty, Akhilender Naidu Kamatham |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Diacylglycerol rich oil Medicine (miscellaneous) Adipose tissue 03 medical and health sciences chemistry.chemical_compound NEFA Internal medicine medicine TX341-641 Total cholesterol LDL-C Diacylglycerol kinase 030109 nutrition & dietetics Nutrition and Dietetics biology Bran medicine.diagnostic_test Nutrition. Foods and food supply urogenital system Cholesterol COX-2 Enzyme assay Nitric oxide synthase Cardiovascular diseases 030104 developmental biology Endocrinology chemistry TNF-α biology.protein lipids (amino acids peptides and proteins) Lipid profile Food Science |
| Zdroj: | Journal of Functional Foods, Vol 40, Iss, Pp 117-127 (2018) |
| ISSN: | 1756-4646 |
| DOI: | 10.1016/j.jff.2017.10.049 |
| Popis: | Diacylglycerol (DAG) oil is suggested to have anti-obesity effect in view of its distinct metabolic fate and fat oxidation. In the present investigation, dietary feeding of DAG rich sunflower and rice bran oils for 12 weeks in Wistar rats significantly decreased triacylglycerol (TAG), total cholesterol and LDL-cholesterol in serum, liver and adipose. Fat accumulation was decreased in DAG fed groups. Fecal cholesterol levels increased in DAG fed rats. DAG rich oil decreased selected cardiovascular disease (CVD) risk factors such as serum C-reactive protein (C-RP), tumor necrosis factor-alpha (TNF-α), platelet aggregation and expression of thoracic aortic proteins such as inducible nitric oxide synthase (i-NOS), cyclooxygenase-2 (COX-2), and vascular cell adhesion molecule-1 (VCAM-1) compared to TAG oil fed group. Serum clinical enzyme activity and histopathological observations of liver conforms safety of DAG oil. Thus, DAG rich oil has beneficial metabolic effects by decreasing fat accumulation, lipid profile and CVD risk factors. |
| Databáze: | OpenAIRE |
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