Liposome-encapsulated peptide PDBSN ameliorates high-fat-diet-induced obesity and improves metabolism homeostasis
Autor: | Xingyun Wang, Ling Chen, Xirong Guo, Jian fang Gao, Dan Shen, Jia Xia, Yahui Zhou, Liling Xu |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Male Population Biophysics Peptide Pharmacology AMP-Activated Protein Kinases Diet High-Fat Biochemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Insulin resistance Adipocyte medicine Animals Homeostasis Obesity education Molecular Biology chemistry.chemical_classification Liposome education.field_of_study L-Lactate Dehydrogenase Chemistry Cell Biology Metabolism medicine.disease Lipid Metabolism Peptide Fragments Enzyme Activation Mice Inbred C57BL 030104 developmental biology Glucose Adipose Tissue 030220 oncology & carcinogenesis Liposomes Anti-Obesity Agents medicine.symptom Weight gain |
Zdroj: | Biochemical and biophysical research communications. 533(1) |
ISSN: | 1090-2104 |
Popis: | In recent years, the obese and overweight population has increased rapidly, which has become a worldwide public health problem. However, effective medication is lacking. Our previous study identified a novel peptide, PDBSN (GLSVADLAESIMKNL), that could significantly restrict adipocyte differentiation in vitro, but its in vivo function has not been determined. Thus, in this study, we encapsulated the peptide into liposomes attached with two ligands (visceral-adipose-tissue-targeting peptide and cell-penetrating peptide) to improve stability and specificity. We then tested the peptide’s function in HFD (high-fat diet)-induced obese mice and found that PDBSN could reduce weight gain and improve insulin resistance as well as lipid homeostasis. These results suggest that PDBSN may be a potential candidate for anti-obesity drug discovery. |
Databáze: | OpenAIRE |
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