Hematopoietic Stem Cells and Regeneration
| Autor: | Mitch Biermann, Tannishtha Reya |
|---|---|
| Rok vydání: | 2024 |
| Předmět: |
Regeneration (biology)
Hematopoietic stem cell hemic and immune systems Biology Hematopoietic Stem Cells Regenerative medicine General Biochemistry Genetics and Molecular Biology Transplantation Haematopoiesis medicine.anatomical_structure Cancer research medicine Bone marrow Stem cell Adult stem cell |
| Zdroj: | Cold Spring Harbor perspectives in biology. 14(8) |
| ISSN: | 1943-0264 |
| Popis: | Hematopoietic stem cell (HSC) regeneration is the remarkable process by which extremely rare, normally inactive cells of the bone marrow can replace an entire organ if called to do so by injury or harnessed by transplantation. HSC research is arguably the first quantitative single-cell science and the foundation of adult stem cell biology. Bone marrow transplant is the oldest and most refined technique of regenerative medicine. Here we review the intertwined history of the discovery of HSCs and bone marrow transplant, the molecular and cellular mechanisms of HSC self-renewal, and the use of HSCs and their derivatives for cell therapy. |
| Databáze: | OpenAIRE |
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