Multidisciplinary Approach for Hypothalamic Obesity in Children and Adolescents: A Preliminary Study
Autor: | P Matarazzo, Alessandra Spinardi, Raffaele Buganza, Giorgia Fenocchio, Antonella Lezo, Ivana Rabbone, Gerdi Tuli, Luisa de Sanctis, Daniele Tessaris, Antonella Tuscano |
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Rok vydání: | 2021 |
Předmět: |
medicine.medical_specialty
hypothalamic obesity 030209 endocrinology & metabolism Overweight Hypothalamic disease Pediatrics RJ1-570 Article 03 medical and health sciences Activity monitoring BMI 0302 clinical medicine Internal medicine medicine 030212 general & internal medicine business.industry Hypothalamic obesity weight gain medicine.disease metformin Weight trend Metformin Pediatrics Perinatology and Child Health medicine.symptom business Weight gain Body mass index medicine.drug |
Zdroj: | Children Children, Vol 8, Iss 531, p 531 (2021) Volume 8 Issue 7 |
ISSN: | 2227-9067 |
Popis: | Hypothalamic obesity (HO) is delineated by an inexorable weight gain in subjects with hypothalamic disorder (congenital or acquired). The aim of the present study was to evaluate the effect of a multidisciplinary approach on weight trend and metabolic outcome in children and adolescents with hypothalamic disease who were overweight or obese. Thirteen patients (aged 8.1–16.1 years) received a personalized diet, accelerometer-based activity monitoring, and psychological assessment. Height, weight, body mass index (BMI), and serum metabolic parameters were assessed at baseline (T0) and after six months (T1). Metformin was introduced at T1 in four subjects who were then re-evaluated after six months (T2). At T1, weight gain was significantly reduced compared with T0 (0.29 ± 0.79 kg/month vs. 0.84 ± 0.55 kg/month, p = 0.03), and weight standard deviation score (SDS) and BMI SDS did not change significantly, as serum metabolic parameters. The four subjects treated with metformin showed a reduction of weight SDS and BMI SDS at T2. In conclusion, patients treated with our multidisciplinary approach showed, after 6 months, favorable results characterized by decreased weight gain and stabilization of weight SDS and BMI SDS in a condition usually characterized by inexorable weight gain. However, further analysis, larger cohorts, and longer follow-up are needed to confirm these preliminary data. |
Databáze: | OpenAIRE |
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