Bioavailability of metformin in tablet form using a new high pressure liquid chromatography assay method
| Autor: | Gilles Caillé, Hélène Landriault, Jean Thiffault, Jean Spénard, Maria Perrotta, Gianfranca Picirilli, Manon Raymond, Y. Lacasse |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Pharmacology Chromatography Chemistry Cmax Biological Availability Pharmaceutical Science Half-life General Medicine High-performance liquid chromatography Metformin Bioavailability Pharmacokinetics medicine Humans Regression Analysis Glucophage Pharmacology (medical) Volunteer Chromatography High Pressure Liquid Half-Life Tablets medicine.drug |
| Zdroj: | Biopharmaceutics & Drug Disposition. 14:257-263 |
| ISSN: | 1099-081X 0142-2782 |
| DOI: | 10.1002/bdd.2510140308 |
| Popis: | Twenty-four young healthy volunteers received a single dose of metformin 500 mg (Glucophage, Nordic Laboratories, Canada) in tablet form. Plasma concentrations were determined by HPLC in samples collected prior to and 0.33, 0.66, 1, 1.33, 1.66, 2, 2.5, 3, 4, 5, 6, 7, 8, 10, 12, 15, 18, 24, and 30 h after dosing. Mean (+/- SD) Cmax was 682.1 (160.6) ng ml-1 at a mean (+/- SD) tmax of 2.4 (0.93) h. Overall elimination was monoexponential with a mean (+/- SD) half-life of 3.16 (0.47) h. We conclude that metformin is rapidly absorbed from this formulation and is also rapidly eliminated. Extrapolation to steady state predicts that equilibrium will be reached within 24 h. |
| Databáze: | OpenAIRE |
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