Dependence of the Cytotoxicity of DNA-Damaging Agents on the Mismatch Repair Status of Human Cells

Autor:	Josef Jiricny, Petr Cejka, Efterpi Papouli
Přispěvatelé:	University of Zurich, Jiricny, J
Rok vydání:	2004
Předmět:	Cancer Research Nitrosourea DNA Repair Base Pair Mismatch Mitomycin Antineoplastic Agents Mutagen Biology medicine.disease_cause Nitrosourea Compounds Cell Line Inhibitory Concentration 50 chemistry.chemical_compound Furocoumarins medicine Humans 1306 Cancer Research Cytotoxicity Antineoplastic Agents Alkylating Melphalan Adaptor Proteins Signal Transducing Etoposide Cisplatin Genetics 10061 Institute of Molecular Cancer Research Mitomycin C Nuclear Proteins digestive system diseases Neoplasm Proteins Oncology chemistry Cell culture Cancer research 570 Life sciences biology Camptothecin 2730 Oncology DNA mismatch repair Drug Screening Assays Antitumor Carrier Proteins MutL Protein Homolog 1 medicine.drug
Zdroj:	Cancer Research. 64:3391-3394
ISSN:	1538-7445 0008-5472
Popis:	Mismatch repair (MMR) deficiency was reported to increase resistance of mammalian cells to killing by several genotoxic substances. However, although MMR-deficient cells are ∼100-fold more resistant to killing by SN1 type methylating agents than MMR-proficient controls, the sensitivity differences reported for the other agents were typically
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99afafb46799457ee18973d710be1f0e https://doi.org/10.1158/0008-5472.can-04-0513 Zobrazit plný text záznamu