Discovery of Highly Potent Dual CysLT1 and CysLT2 Antagonist

Autor:	Jun Takeuchi, Masaki Ima, Shinya Takahashi, Satoshi Itadani, Tetsuya Sekiguchi, Manabu Fujita, Yoshisuke Nakayama
Rok vydání:	2014
Předmět:	business.industry Stereochemistry Organic Chemistry Antagonist Bioinformatics Biochemistry Dual (category theory) chemistry.chemical_compound Text mining chemistry Cysteinyl leukotrienes Drug Discovery Ic50 values Medicine business Derivative (chemistry)
Zdroj:	ACS medicinal chemistry letters. 5(11)
ISSN:	1948-5875
Popis:	The benzoxazine derivative, (2S)-4-(3-carboxypropyl)-8-{[4-(4-phenylbutoxy)benzoyl]amino}-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid (19, ONO-2050297), was identified as the first potent dual CysLT1 and CysLT2 antagonist with IC50 values of 0.017 μM (CysLT1) and 0.00087 μM (CysLT2), respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99af675e66bc22ba29261247752d355c https://pubmed.ncbi.nlm.nih.gov/25408836 Zobrazit plný text záznamu