Genetic Analysis of Drosophila melanogaster Polytene Chromosome Region 44D–45F: Loci Required for Viability and Fertility
| Autor: | Stephanie E. Mohr, Robert E. Boswell |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
Genetics Polytene chromosome biology Egg Proteins Chromosome Mapping Locus (genetics) Sequence Analysis DNA biology.organism_classification Genetic analysis Germline Drosophila melanogaster Fertility Mutation Animals Drosophila Proteins Female Allele Drosophila Protein Research Article Genetic screen |
| Zdroj: | Genetics. 160:1503-1510 |
| ISSN: | 1943-2631 |
| DOI: | 10.1093/genetics/160.4.1503 |
| Popis: | A genetic screen to identify mutations in genes in the 45A region on the right arm of chromosome 2 that are involved in oogenesis in Drosophila was undertaken. Several lethal but no female sterile mutations in the region had previously been identified in screens for P-element insertion or utilizing X rays or EMS as a mutagen. Here we report the identification of EMS-induced mutations in 21 essential loci in the 45D–45F region, including 13 previously unidentified loci. In addition, we isolated three mutant alleles of a newly identified locus required for fertility, sine prole. Mutations in sine prole disrupt spermatogenesis at or before individualization of spermatozoa and cause multiple defects in oogenesis, including inappropriate division of the germline cyst and arrest of oogenesis at stage 4. |
| Databáze: | OpenAIRE |
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