Investigation of nanoformulation and incorporation potential of radiolabeled curcumin using HeLa and MDAH-2774 cells
| Autor: | Mustafa Cosan Terek, Ayfer Yurt Kilcar, Sevki Goksun Gokulu, Nuri Yildirim, Fazilet Zumrut Biber Muftuler, Cansu Kayas, Ahmet Bilgi, Kadriye Busra Karatay |
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| Přispěvatelé: | Ege Üniversitesi |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Health
Toxicology and Mutagenesis macromolecular substances Analytical Chemistry Ovarian endometrioid adenocarcinoma HeLa chemistry.chemical_compound Cervical and ovarian cancer cell lines Radiology Nuclear Medicine and imaging Spectroscopy biology technology industry and agriculture Public Health Environmental and Occupational Health biology.organism_classification Pollution Curcumin (CUR) In vitro PLGA Nuclear Energy and Engineering chemistry Cell culture Curcumin Cancer research Encapsulation Iodine-131 (I-131) Poly(lactic-co-glycolic acid) (PLGA) Radiolabeling |
| Popis: | Nowadays plant origin compounds with anti-cancer properties come into prominence, among them is curcumin (CUR) with a remarkable anti-cancer activity against various cancers. CUR was nanoformulated (CUR-PLGA) by the polymer based poly(lactic-co-glycolic acid) (PLGA) and both CUR and CUR-PLGA were radiolabeled with iodine-131 radionuclide for investigation of their in vitro behaviour on Human cervix adenocarcinoma (HeLa) and Ovarian endometrioid adenocarcinoma (MDAH-2774) cell lines. The newly described radiolabeled CUR and CUR-PLGA may be initiative discovery of novel potential imaging and therapeutic agents. Ege University Scientific Research Projects CoordinationEge University [2017 TIP 044] Current work is supported by Ege University Scientific Research Projects Coordination (Contract No. 2017 TIP 044). The authors thank to Oyku Madenci, Fatmagul Gedik and Nese Kavcar for the technical assistance during the assays. |
| Databáze: | OpenAIRE |
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