| Autor: |
Daeeun Kim, Annie Green Howard, Estela Blanco, Raquel Burrows, Paulina Correa-Burrows, Aylin Memili, Cecilia Albala, José L. Santos, Bárbara Angel, Betsy Lozoff, Anne E. Justice, Penny Gordon-Larsen, Sheila Gahagan, Kari E. North |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Nutr Metab Cardiovasc Dis |
| ISSN: |
0939-4753 |
| Popis: |
BACKGROUND AND AIMS: Adipose tissue secretes adipokines such as adiponectin and leptin, playing important roles in energy metabolism. The longitudinal associations between such adipokines and body fat accumulation have not been established, especially during adolescence and young adulthood and in diverse populations. The study aims to assess the longitudinal association between body fat measured with dual X-ray absorptiometry and plasma adipokines from adolescence to young adulthood. METHODS AND RESULTS: Among Hispanic/Latino participants (N=537) aged 16.8 (SD: 0.3) years of the Santiago Longitudinal Study, we implemented structural equation modeling to estimate the sex-specific associations between adiposity (body fat percent (BF%) and proportion of trunk fat (PTF)) and adipokines (adiponectin and leptin levels) during adolescence (16y) and these values after 6 years of follow-up (22y). In addition, we further investigated whether the associations differed by baseline insulin resistance (IR) status. We found evidence for associations between 16y BF% and 22y leptin levels (β(SE): 0.58(0.06) for females; 0.53(0.05) for males), between 16y PTF and 22y adiponectin levels (β(SE): −0.31(0.06) for females; −0.18(0.06) for males) and between 16y adiponectin levels and 22y BF% (β(SE): 0.12(0.04) for both females and males). CONCLUSION: We observed dynamic relationships between adiposity and adipokines levels from late adolescence to young adulthood in a Hispanic/Latino population further demonstrating the importance of this period of the life course in the development of obesity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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