miR-155–5p predictive role to decelerate foam cell atherosclerosis through CD36, VAV3, and SOCS1 pathway
| Autor: | Nashi Widodo, Umi Kalsum, Ermin Rachmawati, Djanggan Sargowo, M. Saifur Rohman |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Computational biology Biology QH426-470 Endocytosis Biochemistry Article miR-155 03 medical and health sciences 0302 clinical medicine microRNA Genetics Macrophage SOCS1 KEGG Molecular Biology Foam cell Biochemistry (medical) Vav3 Non-coding RNA 030104 developmental biology 030220 oncology & carcinogenesis CD36 Function (biology) miR-155–5p |
| Zdroj: | Non-coding RNA Research, Vol 6, Iss 2, Pp 59-69 (2021) Non-coding RNA Research |
| ISSN: | 2468-0540 |
| Popis: | MicroRNAs (miRNAs) are noncoding RNA molecules that play a significant role in atherosclerosis pathogenesis through post-transcriptional regulation. In the present work, a bioinformatic analysis using TargetScan and miRdB databases was performed to identify the miRNAs targeting three genes involved in foam cell atherosclerosis (CD36, Vav3, and SOCS1). A total number of three hundred and sixty-seven miRNAs were recognized and only miR-155-5p was selected for further evaluation based on Venn analysis. Another objective of this study was to evaluate the biological process and regulatory network of miR-155-5p associated with foam cell atherosclerosis using DIANA, DAVID, Cytoscape, and STRING tools. Additionally, the comprehensive literature review was performed to prove the miR-155-5p function in foam cell atherosclerosis. miR-155-5p might be related with ox-LDL uptake and endocytosis in macrophage cell by targeting CD36 and Vav3 genes which was showed from the KEGG pathways hsa04979, hsa04666, hsa04145 H, hsa04810, and GO:0099632, GO:0060100, GO:0010743, GO:001745. Furthermore, miR-155-5p was also predicted to increase the cholesterol efflux from macrophage by inhibit SOCS1 expression based on KEGG pathway hsa04120. Eleven original studies were included in the review and strongly suggest the role of miR-155-5p in foam cell atherosclerosis inhibition. |
| Databáze: | OpenAIRE |
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