Immunological alterations in the lungs of mice following ozone exposure: changes in immunoglobulin levels and antibody-containing cells
| Autor: | Sally Owens, Yuan Chung Zee, William M. Dotson, John W. Osebold, David D. LaBarre |
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| Rok vydání: | 1979 |
| Předmět: |
Globulin
Serum albumin Immunoglobulins Mice Blood serum Ozone Antigen Albumins medicine Environmental Chemistry Animals Germ-Free Life Respiratory system Antibody-Producing Cells Lung General Environmental Science biology Chemistry Public Health Environmental and Occupational Health Immunity respiratory system Immunoglobulin A Immunodiffusion medicine.anatomical_structure Immunoglobulin M Immunology biology.protein Antibody Extracellular Space |
| Zdroj: | Archives of environmental health. 34(4) |
| ISSN: | 0003-9896 |
| Popis: | Ozone was added to the air of environmental chambers containing specific pathogen-free mice. At levels of 0.5 and 0.8 ppm the oxidant was seen to have inflammatory effects, as shown by rising serum albumin levels in lung lavage fluid. Fluorescein conjugated anti-heavy chain sera were used to detect cells containing IgM, IgG, and IgA in measured lung areas termed Pulmonary Units. Antigenic stimuli occurred along the airways, with significant increases of IgA-containing cells in the bronchus-associated lymphoid tissue. The numbers of IgM- and IgG-containing cells did not increase. Immunodiffusion analyses for immunoglobulins in lung lavage fluid indicated increases of IgG1 IgG2, and IgA in lung secretions. The calculation of changing Ig/Alb ratios suggested that the IgA present was largely the result of local synthesis, while IgG molecules were mainly of serum origin. Possible sources of the antigenic stimuli to ozone-exposed lungs are discussed. |
| Databáze: | OpenAIRE |
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