Do TRPC channels support working memory? Comparing modulations of TRPC channels and working memory through G-protein coupled receptors and neuromodulators
| Autor: | Frederik M. Theissen, Maria J. Valero-Aracama, Mihaela A. Corbu, Antonio Reboreda, Alberto Arboit, Motoharu Yoshida |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Serotonin physiology [Acetylcholine] Computer science Dopamine physiology [Hippocampus] physiology [Serotonin] Hippocampus Action Potentials physiology [Receptors G-Protein-Coupled] Receptors G-Protein-Coupled 03 medical and health sciences Behavioral Neuroscience Transient receptor potential channel Norepinephrine 0302 clinical medicine physiology [Dopamine] Conditioning Psychological Animals Humans ddc:610 physiology [TRPC Cation Channels] TRPC G protein-coupled receptor TRPC Cation Channels Neurons Mechanism (biology) Working memory physiology [Neurons] Acetylcholine 030104 developmental biology physiology [Norepinephrine] Memory Short-Term Channel types physiology [Memory Short-Term] Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Behavioural brain research 354, 64-83 (2018). doi:10.1016/j.bbr.2018.02.042 |
| ISSN: | 1872-7549 |
| DOI: | 10.1016/j.bbr.2018.02.042 |
| Popis: | Working memory is a crucial ability we use in daily life. However, the cellular mechanisms supporting working memory still remain largely unclear. A key component of working memory is persistent neural firing which is believed to serve short-term (hundreds of milliseconds up to tens of seconds) maintenance of necessary information. In this review, we will focus on the role of transient receptor potential canonical (TRPC) channels as a mechanism underlying persistent firing. Many years of in vitro work have been suggesting a crucial role of TRPC channels in working memory and temporal association tasks. If TRPC channels are indeed a central mechanism for working memory, manipulations which impair or facilitate working memory should have a similar effect on TRPC channel modulation. However, modulations of working memory and TRPC channels were never systematically compared, and it remains unanswered whether TRPC channels indeed contribute to working memory in vivo or not. In this article, we review the effects of G-protein coupled receptors (GPCR) and neuromodulators, including acetylcholine, noradrenalin, serotonin and dopamine, on working memory and TRPC channels. Based on comparisons, we argue that GPCR and downstream signaling pathways that activate TRPC, generally support working memory, while those that suppress TRPC channels impair it. However, depending on the channel types, areas, and systems tested, this is not the case in all studies. Further work to clarify involvement of specific TRPC channels in working memory tasks and how they are affected by neuromodulators is still necessary in the future. |
| Databáze: | OpenAIRE |
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