A risk factor for newly diagnosed secondary cancer in patients with early-stage laryngeal, oropharyngeal, or hypopharyngeal cancer: sub-analysis of a prospective observation study
Autor: | Yohei Hiiragi, Hideaki Takahashi, Yosuke Kitani, Daisuke Sano, Kentaro Takada, Nobuhiko Oridate, Goshi Nishimura, Takashi Hatano, Takashi Wada, Yasuhiro Arai |
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Rok vydání: | 2021 |
Předmět: |
Oncology
medicine.medical_specialty Risk Factors Surgical oncology Internal medicine medicine Humans Prospective Studies Stage (cooking) Risk factor Laryngeal Neoplasms Retrospective Studies Hypopharyngeal Neoplasms business.industry Incidence (epidemiology) Cancer Hypopharyngeal cancer Hematology General Medicine medicine.disease Confidence interval Head and Neck Neoplasms Cohort Carcinoma Squamous Cell Surgery business |
Zdroj: | International Journal of Clinical Oncology. 27:488-494 |
ISSN: | 1437-7772 1341-9625 |
Popis: | We previously identified hypopharyngeal cancer as an independent risk factor for the incidence of newly diagnosed secondary cancers after the treatment of early-stage laryngeal, oropharyngeal, and hypopharyngeal cancers. We subsequently used a different patient cohort to validate the usefulness of this factor during the follow-up period in these patients. Patients who underwent transoral surgery (TOS) as a definitive treatment between April 1, 2016, and September 30, 2020, were included. The incidence of secondary cancer was evaluated in hypopharyngeal and other cancers. Overall survival (OS), recurrence-free survival (RFS), and disease-free survival (DFS) outcomes were evaluated. Statistical analyses based on the risk factors were also performed. Incidence of new secondary cancer was 30% in hypopharyngeal cancer patients as compared to 11% in other cancer patients, and the risk was 3.60-fold (95% confidence interval 1.07–12.10) higher after definitive treatment for initial head and neck cancers. The 3-year OS, RFS, and DFS rates were 98%, 86%, and 67%, respectively. Among patients with early-stage laryngeal, oropharyngeal, and hypopharyngeal squamous cell carcinoma, who were initially treated with TOS, hypopharyngeal cancer patients had a higher risk of newly diagnosed secondary cancers as observed during the follow-up period. |
Databáze: | OpenAIRE |
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