Comprehensive Evidence-Based Assessment and Prioritization of Potential Antidiabetic Medicinal Plants: A Case Study from Canadian Eastern James Bay Cree Traditional Medicine
| Autor: | Emma Coon Come, Steffany A. L. Bennett, Louise Etapp, John T. Arnason, Alex Weistche, Andrew Kawapit, Laurie Petawabano, Josephine Diamond, Louis C. Martineau, Alain Cuerrier, Rene Coon Come, Lina Musallam, Charlotte Husky Swallow, John Petagumskum, Eliza Mamianskum, Timothy Johns, Alaa Badawi, Brian C. Foster, Smalley Petawabano, Mary Jolly, Louis Lavoie, Pierre S. Haddad, Johnny Husky Swallow, Jimmy George, Cory S. Harris, Charlie Etapp |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
2. Zero hunger
High rate Prioritization 0303 health sciences medicine.medical_specialty Traditional medicine business.industry Alternative medicine 030209 endocrinology & metabolism Review Article lcsh:Other systems of medicine lcsh:RZ201-999 Alternative treatment 3. Good health 03 medical and health sciences 0302 clinical medicine Complementary and alternative medicine Ethnobotany Molecular targets Medicine business Medicinal plants Evidence based assessment 030304 developmental biology |
| Zdroj: | Evidence-Based Complementary and Alternative Medicine, Vol 2012 (2012) Evidence-based Complementary and Alternative Medicine : eCAM |
| ISSN: | 1741-4288 |
| Popis: | Canadian Aboriginals, like others globally, suffer from disproportionately high rates of diabetes. A comprehensive evidence-based approach was therefore developed to study potential antidiabetic medicinal plants stemming from Canadian Aboriginal Traditional Medicine to provide culturally adapted complementary and alternative treatment options. Key elements of pathophysiology of diabetes and of related contemporary drug therapy are presented to highlight relevant cellular and molecular targets for medicinal plants. Potential antidiabetic plants were identified using a novel ethnobotanical method based on a set of diabetes symptoms. The most promising species were screened for primary (glucose-lowering) and secondary (toxicity, drug interactions, complications) antidiabetic activity by using a comprehensive platform ofin vitrocell-based and cell-free bioassays. The most active species were studied further for their mechanism of action and their active principles identified though bioassay-guided fractionation. Biological activity of key species was confirmed in animal models of diabetes. Thesein vitroandin vivofindings are the basis for evidence-based prioritization of antidiabetic plants. In parallel, plants were also prioritized by Cree Elders and healers according to their Traditional Medicine paradigm. This case study highlights the convergence of modern science and Traditional Medicine while providing a model that can be adapted to other Aboriginal realities worldwide. |
| Databáze: | OpenAIRE |
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