Dactylocyclines, novel tetracycline derivatives produced by a Dactylosporangium sp. I. Taxonomy, production, isolation and biological activity
| Autor: | Adrienne A. Tymiak, P. Principe, Joseph O'sullivan, William H. Trejo, Donald R. Kirsch, J S Wells, Helen A. Ax, Carol Ann Aklonis |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Pharmacology
Chlortetracycline Magnetic Resonance Spectroscopy biology Spectrophotometry Infrared Tetracycline Gram-positive bacteria Tetracycline Resistance Dactylosporangium Microbial Sensitivity Tests biology.organism_classification Gram-Positive Bacteria Microbiology Anti-Bacterial Agents Biochemistry Drug Discovery Actinomycetales Gram-Negative Bacteria medicine Fermentation Bacteria Antibacterial agent medicine.drug |
| Zdroj: | The Journal of antibiotics. 45(12) |
| ISSN: | 0021-8820 |
| Popis: | A screen for antibiotics with activity against tetracycline-resistant microorganisms has led to the isolation of Dactylosporangium sp. (ATCC 53693), a producer of several novel tetracycline derivatives. The major fermentation products, dactylocyclines A and B, were purified and MIC values determined against tetracycline-resistant and tetracycline-sensitive Gram-positive bacteria. The dactylocyclines represent the first naturally occurring tetracycline C2 amides which lack cross resistance with tetracycline. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|