The function of the bacterial cytoskeleton in Salmonella pathogenesis
| Autor: | Anne C. Doble, Kharraz L, David M. Bulmer, Michail H. Karavolos, C. M. A. Khan |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Microbiology (medical)
Immunology Virulence Flagellum Biology Models Biological Microbiology MreB Type three secretion system Prokaryotic cytoskeleton 03 medical and health sciences Bacterial Proteins Salmonella Cytoskeleton News and Views Actin 030304 developmental biology 0303 health sciences 030306 microbiology cytoskeleton Pathogenicity island Cell biology virulence Infectious Diseases type 3 secretion Parasitology flagella |
| Zdroj: | Virulence |
| ISSN: | 2150-5608 2150-5594 |
| DOI: | 10.4161/viru.20993 |
| Popis: | Recent studies have identified cytoskeletal elements in bacteria which play important roles in cellular morphology, cell division, DNA segregation and the establishment of cell polarity. However, our understanding of the contribution the bacterial cytoskeleton makes toward virulence is lacking. The MreB protein is a bacterial homolog of eukaryotic actin and interacts intimately with MreC and MreD. We provide evidence that the Mre-based cytoskeleton directly influences pathogenicity in Salmonella. Disruption of MreC and MreD caused the downregulation of the Salmonella pathogenicity island 1 (SPI-1) type 3 secretion system (T3SS) essential for host cell-invasion, and also flagella-mediated motility. These phenotypic effects were mediated by RcsC, the sensor kinase of the Rcs phosphorelay two-component system and a major envelope stress regulator. Curiously, the SPI-2 T3SS remained viable. Our results demonstrate the importance of the integrity of the bacterial cytoskeleton for virulence, highlighting the impact of associated global regulatory mechanisms on pathogenicity. |
| Databáze: | OpenAIRE |
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