| Popis: |
SUMMARY The therapeutic activity of 3,3-bis-(2-imidazolin-2-yl) carbanilide dihydrochloride (imidocarb dihydrochloride), in doses from 1 to 6 mg/kg bodyweight, was evaluated against experimental infection with a virulent strain of Babesia ovis in sheep. The administration of imidocarb 2HCl at less than 6 mg/kg bodyweight was found to be ineffective in eliminating the parasites, and relapses occurred. Subcutaneous administration of the drug in divided doses of 2 mg/kg for three days proved to be highly effective and no relapses occurred among the 27 treated splenectomized lambs. Subcutaneous inoculation of blood from these treated lambs into clean, splenetomized lambs indicated complete elimination of the parasites. Symptoms suggestive of toxicity of the drug were observed following a single injection of 10 mg/kg bodyweight, but not after repeated lower dosages. In a comparative study, N,N-(dimethylquinolylium-methylsulphate-6-)-urea (quinuronium sulphate), at a dose of 1 mg/kg was ineffective in eliminating B. ovis. The margin of safety of quinuronium sulphate was small, toxic effects being observed with doses of 1 mg/kg bodyweight, even in divided doses of 0.5 mg/kg/day. |
