Comparative Analysis of Eleven Healthcare-Associated Outbreaks of Middle East Respiratory Syndrome Coronavirus (Mers-Cov) from 2015 to 2017

Autor: Sibylle Bernard-Stoecklin, Mamunur Rahman Malik, Abdullah M. Assiri, Birgit Nikolay, Maria D. Van Kerkhove, Hassan El Bushra, Moran Ki, Simon Cauchemez, Abdul Aziz Bin Saeed, Arnaud Fontanet, Peter Ben Embarek
Přispěvatelé: Center for Global Health Research and Education - Centre pour la Recherche et la Formation en Santé Mondiale (CGH), Institut Pasteur [Paris]-Réseau International des Instituts Pasteur (RIIP), Modélisation mathématique des maladies infectieuses - Mathematical modelling of Infectious Diseases, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Ministry of Health [Riyadh], Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), National Cancer Center Korea, Regional Office for the Eastern Mediterranean [Cairo] (EMRO), Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology, Pasteur-Cnam Risques infectieux et émergents (PACRI), Institut Pasteur [Paris]-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Institut Pasteur [Paris]-Conservatoire National des Arts et Métiers [CNAM] (CNAM), Conservatoire National des Arts et Métiers [CNAM] (CNAM), B.N. and S.C. acknowledge financial support from the Investissement d’Avenir program, the Laboratoire d’Excellence Integrative Biology of Emerging Infectious Diseases program (Grant ANR-10-LABX-62-IBEID), the Models of Infectious Disease Agent Study of the National Institute of General Medical Sciences, the AXA Research Fund and the INCEPTION project (PIA/ANR-16-CONV-0005)., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), ANR-16-CONV-0005,INCEPTION,Institut Convergences pour l'étude de l'Emergence des Pathologies au Travers des Individus et des populatiONs(2016), Institut Pasteur [Paris] (IP)-Réseau International des Instituts Pasteur (RIIP), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), WHO - Regional Office for the Eastern Mediterranean [Cairo, Egypt] (EMRO), Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Male
Multivariate analysis
MESH: Coronavirus Infections
lcsh:Medicine
MESH: Infectious Disease Transmission
Professional-to-Patient

MESH: Comorbidity
Comorbidity
medicine.disease_cause
Disease Outbreaks
Infectious Disease Transmission
Professional-to-Patient

0302 clinical medicine
Healthcare associated
MESH: Risk Factors
[MATH.MATH-ST]Mathematics [math]/Statistics [math.ST]
Health care
Epidemiology
MESH: Disease Outbreaks
lcsh:Science
MESH: Aged
Cross Infection
Multidisciplinary
MESH: Middle Aged
Transmission (medicine)
Age Factors
Middle Aged
MESH: Hospitals
Hospitals
3. Good health
Middle East Respiratory Syndrome Coronavirus
Infectious diseases
Female
Coronavirus Infections
MESH: History
21st Century

Adult
MESH: Republic of Korea
medicine.medical_specialty
Infectious Disease Transmission
Patient-to-Professional

Middle East respiratory syndrome coronavirus
Health Personnel
Saudi Arabia
History
21st Century

World health
Article
03 medical and health sciences
Environmental health
MESH: Infectious Disease Transmission
Patient-to-Professional

Republic of Korea
medicine
Humans
Aged
MESH: Age Factors
MESH: Humans
business.industry
lcsh:R
MESH: Middle East Respiratory Syndrome Coronavirus
Outbreak
MESH: Cross Infection
MESH: Adult
MESH: Male
MESH: Saudi Arabia
030104 developmental biology
Risk factors
MESH: Health Personnel
lcsh:Q
business
MESH: Female
030217 neurology & neurosurgery
Zdroj: Scientific Reports
Scientific Reports, Nature Publishing Group, 2019, 9 (1), pp.7385. ⟨10.1038/s41598-019-43586-9⟩
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports, 2019, 9 (1), pp.7385. ⟨10.1038/s41598-019-43586-9⟩
ISSN: 2045-2322
DOI: 10.1038/s41598-019-43586-9⟩
Popis: Since its emergence in 2012, 2,260 cases and 803 deaths due to Middle East respiratory syndrome coronavirus (MERS-CoV) have been reported to the World Health Organization. Most cases were due to transmission in healthcare settings, sometimes causing large outbreaks. We analyzed epidemiologic and clinical data of laboratory-confirmed MERS-CoV cases from eleven healthcare-associated outbreaks in the Kingdom of Saudi Arabia and the Republic of Korea between 2015–2017. We quantified key epidemiological differences between outbreaks. Twenty-five percent (n = 105/422) of MERS cases who acquired infection in a hospital setting were healthcare personnel. In multivariate analyses, age ≥65 (OR 4.8, 95%CI: 2.6–8.7) and the presence of underlying comorbidities (OR: 2.7, 95% CI: 1.3–5.7) were associated with increased mortality whereas working as healthcare personnel was protective (OR 0.07, 95% CI: 0.01–0.34). At the start of these outbreaks, the reproduction number ranged from 1.0 to 5.7; it dropped below 1 within 2 to 6 weeks. This study provides a comprehensive characterization of MERS HCA-outbreaks. Our results highlight heterogeneities in the epidemiological profile of healthcare-associated outbreaks. The limitations of our study stress the urgent need for standardized data collection for high-threat respiratory pathogens, such as MERS-CoV.
Databáze: OpenAIRE