Comparative Analysis of Eleven Healthcare-Associated Outbreaks of Middle East Respiratory Syndrome Coronavirus (Mers-Cov) from 2015 to 2017
Autor: | Sibylle Bernard-Stoecklin, Mamunur Rahman Malik, Abdullah M. Assiri, Birgit Nikolay, Maria D. Van Kerkhove, Hassan El Bushra, Moran Ki, Simon Cauchemez, Abdul Aziz Bin Saeed, Arnaud Fontanet, Peter Ben Embarek |
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Přispěvatelé: | Center for Global Health Research and Education - Centre pour la Recherche et la Formation en Santé Mondiale (CGH), Institut Pasteur [Paris]-Réseau International des Instituts Pasteur (RIIP), Modélisation mathématique des maladies infectieuses - Mathematical modelling of Infectious Diseases, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Ministry of Health [Riyadh], Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), National Cancer Center Korea, Regional Office for the Eastern Mediterranean [Cairo] (EMRO), Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology, Pasteur-Cnam Risques infectieux et émergents (PACRI), Institut Pasteur [Paris]-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Institut Pasteur [Paris]-Conservatoire National des Arts et Métiers [CNAM] (CNAM), Conservatoire National des Arts et Métiers [CNAM] (CNAM), B.N. and S.C. acknowledge financial support from the Investissement d’Avenir program, the Laboratoire d’Excellence Integrative Biology of Emerging Infectious Diseases program (Grant ANR-10-LABX-62-IBEID), the Models of Infectious Disease Agent Study of the National Institute of General Medical Sciences, the AXA Research Fund and the INCEPTION project (PIA/ANR-16-CONV-0005)., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), ANR-16-CONV-0005,INCEPTION,Institut Convergences pour l'étude de l'Emergence des Pathologies au Travers des Individus et des populatiONs(2016), Institut Pasteur [Paris] (IP)-Réseau International des Instituts Pasteur (RIIP), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), WHO - Regional Office for the Eastern Mediterranean [Cairo, Egypt] (EMRO), Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM) |
Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Male Multivariate analysis MESH: Coronavirus Infections lcsh:Medicine MESH: Infectious Disease Transmission Professional-to-Patient MESH: Comorbidity Comorbidity medicine.disease_cause Disease Outbreaks Infectious Disease Transmission Professional-to-Patient 0302 clinical medicine Healthcare associated MESH: Risk Factors [MATH.MATH-ST]Mathematics [math]/Statistics [math.ST] Health care Epidemiology MESH: Disease Outbreaks lcsh:Science MESH: Aged Cross Infection Multidisciplinary MESH: Middle Aged Transmission (medicine) Age Factors Middle Aged MESH: Hospitals Hospitals 3. Good health Middle East Respiratory Syndrome Coronavirus Infectious diseases Female Coronavirus Infections MESH: History 21st Century Adult MESH: Republic of Korea medicine.medical_specialty Infectious Disease Transmission Patient-to-Professional Middle East respiratory syndrome coronavirus Health Personnel Saudi Arabia History 21st Century World health Article 03 medical and health sciences Environmental health MESH: Infectious Disease Transmission Patient-to-Professional Republic of Korea medicine Humans Aged MESH: Age Factors MESH: Humans business.industry lcsh:R MESH: Middle East Respiratory Syndrome Coronavirus Outbreak MESH: Cross Infection MESH: Adult MESH: Male MESH: Saudi Arabia 030104 developmental biology Risk factors MESH: Health Personnel lcsh:Q business MESH: Female 030217 neurology & neurosurgery |
Zdroj: | Scientific Reports Scientific Reports, Nature Publishing Group, 2019, 9 (1), pp.7385. ⟨10.1038/s41598-019-43586-9⟩ Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019) Scientific Reports, 2019, 9 (1), pp.7385. ⟨10.1038/s41598-019-43586-9⟩ |
ISSN: | 2045-2322 |
DOI: | 10.1038/s41598-019-43586-9⟩ |
Popis: | Since its emergence in 2012, 2,260 cases and 803 deaths due to Middle East respiratory syndrome coronavirus (MERS-CoV) have been reported to the World Health Organization. Most cases were due to transmission in healthcare settings, sometimes causing large outbreaks. We analyzed epidemiologic and clinical data of laboratory-confirmed MERS-CoV cases from eleven healthcare-associated outbreaks in the Kingdom of Saudi Arabia and the Republic of Korea between 2015–2017. We quantified key epidemiological differences between outbreaks. Twenty-five percent (n = 105/422) of MERS cases who acquired infection in a hospital setting were healthcare personnel. In multivariate analyses, age ≥65 (OR 4.8, 95%CI: 2.6–8.7) and the presence of underlying comorbidities (OR: 2.7, 95% CI: 1.3–5.7) were associated with increased mortality whereas working as healthcare personnel was protective (OR 0.07, 95% CI: 0.01–0.34). At the start of these outbreaks, the reproduction number ranged from 1.0 to 5.7; it dropped below 1 within 2 to 6 weeks. This study provides a comprehensive characterization of MERS HCA-outbreaks. Our results highlight heterogeneities in the epidemiological profile of healthcare-associated outbreaks. The limitations of our study stress the urgent need for standardized data collection for high-threat respiratory pathogens, such as MERS-CoV. |
Databáze: | OpenAIRE |
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