Cytolytic Antibodies to Melanocytes in Vitiligo
| Autor: | Yuko Arita, Jian Cui, Jean-Claude Bystryn |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Cytotoxicity
Immunologic Vitiligo Dermatology Biology Melanocyte Severity of Illness Index Biochemistry Antibodies Europium Antibody Specificity Methods medicine Humans Functional ability skin and connective tissue diseases Molecular Biology Pigmentation disorder Autoimmune disease integumentary system Autoantibody Cell Biology medicine.disease Cytolysis medicine.anatomical_structure Immunology biology.protein Melanocytes Antibody |
| Zdroj: | Journal of Investigative Dermatology. 100(6):812-815 |
| ISSN: | 0022-202X |
| DOI: | 10.1111/1523-1747.ep12476636 |
| Popis: | Patients with vitiligo have been found to have circulating antibodies to pigment cells. To evaluate the functional activity of these antibodies, a highly sensitive europium release assay was used to compare complement-mediated cytolysis of human melanocytes by sera of 56 patients with vitiligo (20 with active disease, 25 with inactive disease, 11 with unidentified disease activity) and 47 control individuals. Significant melanocyte lysis was mediated by 32 (57%) of the patients with vitiligo but by only three (6%) of the control sera (p < 0.00 1), and by 17 (85%) of 20 patients with active vitiligo versus 11(44%) of 25 patients with inactive disease (p < 0.025). Mean melanocyte lysis by vitiligo sera was 24% versus 6% by control sera (p |
| Databáze: | OpenAIRE |
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