Association between the insulin-like growth factor axis in serum and periodontitis in the Study of Health in Pomerania: an exploratory study
| Autor: | Ali N. Harb, Nele Friedrich, Reiner Biffar, Martin Albers, Henri Wallaschofski, Matthias Nauck, Peter Meisel, Birte Holtfreter, Thomas Kocher |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
medicine.medical_specialty Cross-sectional study medicine.medical_treatment Population Dentistry Logistic regression Gastroenterology Insulin-like growth factor Tooth Loss Young Adult Internal medicine Germany Periodontal Attachment Loss medicine Tooth loss Humans Insulin-Like Growth Factor I education Periodontitis education.field_of_study business.industry DMF Index Middle Aged medicine.disease stomatognathic diseases Cross-Sectional Studies Insulin-Like Growth Factor Binding Protein 3 Clinical attachment loss Study of Health in Pomerania Periodontics medicine.symptom business |
| Zdroj: | Journal of clinical periodontology. 39(10) |
| ISSN: | 1600-051X |
| Popis: | Aim To evaluate the association of Insulin-like Growth Factor (IGF) I-related variables with periodontitis in the population-based Study of Health in Pomerania (SHIP). Material and Methods From the cross-sectional SHIP, 2293 subjects with clinical attachment loss (CAL) data and 2398 subjects with tooth count data aged 20–59 years were analysed. Serum IGF-I and IGF-binding protein (BP)-3 levels were determined by chemiluminescence immunoassays. Linear and logistic regressions with fractional polynomials were used to study associations between IGF-related variables and mean CAL or high tooth loss. For non-linear relations between IGFBP-3 and mean CAL, graphical presentations of fractional polynomials were used to deduce knots for linear splines. Results In fully adjusted models, for serum IGFBP-3 values ≤1200 ng/ml, mean CAL increased significantly for decreasing serum IGFBP-3 levels [B = −0.027 (95% CI, −0.049; −0.005), p = 0.02]. The odds for high tooth loss decreased significantly for high serum IGFBP-3 values [OR = 0.97 (0.95; 0.99), p = 0.02]. Serum IGF-I levels and the IGF-I/IGFBP-3 ratio were not related to mean CAL or tooth loss after full adjustment. Conclusions Low serum IGFBP-3 levels might be associated with higher levels of periodontal disease. Neither serum IGF-I nor IGF-I/IGFBP-3 ratios were associated with periodontitis. |
| Databáze: | OpenAIRE |
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