Severe Toxic Effect of Methylene Blue 1% on Iris Epithelium and Corneal Endothelium
| Autor: | Dimitrios Brouzas, Ioannis Malias, Dimitrios Droutsas, Michael Moschos, Efstratia Georgiadou, Antonios Charakidas, Michael Apostolopoulos |
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| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
Corneal endothelium genetic structures Endothelium medicine.medical_treatment Iris pigment dispersion Vision Disorders Iris Epithelium chemistry.chemical_compound Ophthalmology medicine Humans Enzyme Inhibitors Iris epithelium Phacoemulsification business.industry Corneal Edema Endothelium Corneal Middle Aged Cataract surgery eye diseases Surgery Staining Methylene Blue medicine.anatomical_structure Iris Diseases chemistry Female sense organs business Keratoplasty Penetrating Methylene blue |
| Zdroj: | Cornea. 25:470-471 |
| ISSN: | 0277-3740 |
| DOI: | 10.1097/01.ico.0000183488.78012.33 |
| Popis: | To report a case of corneal endothelial decompensation and iris pigment dispersion following the inadvertent use of methylene blue 1% for capsular staining during cataract surgery.Case report.During an otherwise routine phacoemulsification cataract surgery, inadvertent anterior capsule staining with methylene blue 1% instead of trypan blue 0.025% was performed. Copious irrigation of the anterior chamber with balanced salt solution was initiated upon identification of the wrong dye. The operation was completed with minimal ultrasound energy without complications.Iris discoloration and severe corneal edema developed in the early postoperative period, resulting in severe visual loss. The patient developed bullous keratopathy and underwent penetrating keratoplasty 16 months later.In vivo intracameral injection of methylene blue 1% induces extreme cytotoxicity, primarily on the corneal endothelium and iris epithelium. |
| Databáze: | OpenAIRE |
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