Inhibition of levodopa effects by internal pallidal stimulation
| Autor: | Patricia Limousin, Pierre Pollak, Abdelhamid Benazzouz, Alim-Louis Benabid, Paul Krack, Dominique Hoffmann |
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| Jazyk: | angličtina |
| Rok vydání: | 1998 |
| Předmět: |
Male
Dyskinesia Drug-Induced Levodopa Parkinson's disease Stimulation Electric Stimulation Therapy Neurological disorder Globus Pallidus Antiparkinson Agents Central nervous system disease Levodopa/administration & dosage/adverse effects Basal ganglia medicine Humans Dominance Cerebral Parkinson Disease/physiopathology/therapy Dominance Cerebral/drug effects/physiology business.industry Parkinsonism Parkinson Disease Globus Pallidus/drug effects/physiopathology Middle Aged medicine.disease Antiparkinson Agents/administration & dosage/adverse effects Combined Modality Therapy nervous system diseases Electrodes Implanted Dyskinesia Drug-Induced/diagnosis/physiopathology/therapy Neurology Dyskinesia Anesthesia Neurology (clinical) medicine.symptom business Neuroscience medicine.drug |
| Zdroj: | Movement Disorders, Vol. 13, No 4 (1998) pp. 648-52 |
| ISSN: | 0885-3185 |
| Popis: | We report three patients with bilateral GPi stimulation for stage 4 Parkinson's disease (PD) with severe levodopa-induced dyskinesias (LID). In all three it was possible to completely inhibit LID using high-stimulation parameters. Parallel to complete inhibition of LID, an inhibition of the anti-akinetic effect of levodopa was observed, whereas, at the same time, rigidity was markedly improved. GPi stimulation is adaptable over time, and stimulation parameters have to be programmed according to off- and on-period motor symptoms. The main interest of stimulation is the possibility of finding a compromise between LID alleviation in on-phase without loss of the beneficial motor effects and improvement in parkinsonism in off-phase. In some patients, residual dyskinesias have to be accepted so as not to aggravate on-period motor symptoms by a presumed overinhibition of basal ganglia outflow. |
| Databáze: | OpenAIRE |
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