Long-lasting alterations in adipose tissue density and adiponectin production in people living with HIV after thymidine analogues exposure
Autor: | Marco Gelpi, Andreas Dehlbæk Knudsen, Karoline Brostrup Larsen, Amanda Mocroft, Anne-Mette Lebech, Birgitte Lindegaard, Jens Lundgren, Klaus Fuglsang Kofoed, Susanne Dam Nielsen, on behalf of the Copenhagen Comorbidity in HIV Infection (COCOMO) Study |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Anti-HIV Agents 030106 microbiology Subcutaneous Fat Adipose tissue HIV Infections Intra-Abdominal Fat Logistic regression lcsh:Infectious and parasitic diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Adipocyte Internal medicine parasitic diseases Adipose tissue function medicine Adipocytes Humans lcsh:RC109-216 Longitudinal Studies 030212 general & internal medicine Visceral fat Didanosine Adiponectin business.industry Absolute risk reduction HIV Venous blood Middle Aged Discontinuation Cross-Sectional Studies Infectious Diseases Endocrinology Adipose Tissue chemistry Female business Biomarkers Thymidine Research Article medicine.drug |
Zdroj: | BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-8 (2019) Gelpi, M, Knudsen, A D, Larsen, K B, Mocroft, A, Lebech, A M, Lindegaard, B, Lundgren, J, Kofoed, K F & Nielsen, S D 2019, ' Long-lasting alterations in adipose tissue density and adiponectin production in people living with HIV after thymidine analogues exposure ', BMC Infectious Diseases, vol. 19, no. 1, 708 . https://doi.org/10.1186/s12879-019-4347-y BMC Infectious Diseases |
ISSN: | 1471-2334 |
Popis: | Background Thymidine analogues (TA) and didanosine (ddI) are associated with long-lasting adipose tissue redistribution. Adiponectin is a widely used marker of adipocyte activity, and adipose tissue density assessed by CT-scan is associated with adipocyte size and function. We hypothesized that prior exposure to TA and ddI was associated with long-lasting adipose tissue dysfunction in people living with HIV (PLWH). Thus, we tested possible associations between markers of adipose tissue dysfunction (adipose tissue density and adiponectin) and prior exposure to TA and/or ddI, years after treatment discontinuation. Methods Eight hundred forty-eight PLWH from the COCOMO study were included and stratified according to prior exposure to TA and/or ddI (with, n = 451; without n = 397). Visceral (VAT) and subcutaneous (SAT) adipose tissue area and density were determined by single slice abdominal CT-scan at lumbar 4th level. Venous blood was collected and analyzed for adiponectin. Multivariable linear and logistic regression analyses were used to test our hypotheses. Multivariable models were adjusted for age, sex, smoking, origin, physical activity, BMI, and adipose tissue area (VAT or SAT area, accordingly to the outcome). Results prior exposure to TA and/or ddI was associated with excess risk of low VAT (adjusted OR (aOR) 1.74 [1.14; 2.67]) and SAT density (aOR 1.74 [1.18; 2.58]), for a given VAT and SAT area, respectively. No association between VAT and SAT density with time since TA and/or ddI discontinuation was found. 10 HU increase in VAT density was associated with higher adiponectin plasma level and this association was not modified by prior exposure to TA and/or ddI. Prior exposure to TA and/or ddI was associated with 9% lower [− 17;-2] plasma adiponectin levels and with excess risk of low adiponectin (aOR 1.74 [1.10; 2.76]). Conclusions We described low adipose tissue density and impaired adiponectin production to be associated with prior exposure to TA and/or ddI even years after treatment discontinuation and independently of adipose tissue area. These findings suggest that prior TA and ddI exposure may have long-lasting detrimental effects on adipose tissue function and, consequently, on cardiometabolic health in PLWH. Electronic supplementary material The online version of this article (10.1186/s12879-019-4347-y) contains supplementary material, which is available to authorized users. |
Databáze: | OpenAIRE |
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