High-fat diet promotes colorectal carcinogenesis through SERCA2 mediated serine phosphorylation of Annexin A2

Autor:	Lu Fan, Cai Lu, Ye Fan, Xinyi Tian, Sinan Lu, Pengfei Zhang, Ziyu Li, Mei Xue, Weiwei Tao, Fang Peng, Ruini Chen, Juanjuan Tang, Ming Zhao
Rok vydání:	2021
Předmět:	Mice Inbred C57BL Mice Carcinogenesis Serine Animals Humans Cell Biology Mice SCID Phosphorylation Colorectal Neoplasms Diet High-Fat Biochemistry Annexin A2
Zdroj:	The international journal of biochemistrycell biology. 145
ISSN:	1878-5875
Popis:	Colorectal cancer (CRC) is a highly common malignancy, being the third leading cause of cancer death worldwide. Recent epidemiological studies have indicated that carcinogenic effect of diet was mainly attributed to high-fat diets. To investigate the mechanism of high-fat diet-induced colorectal cancer, we systematically quantified the phosphoproteome in human HT-29 cells treated with sodium palmitate (PA). p-Annexin A2 (S26) was predicted to be specifically up-regulated by PA. We confirmed that PA-induced Annexin A2 phosphorylation at Ser26 in C57BL/6 J-Apc
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a1b5b305eee94d450ec31c3af1c583 https://pubmed.ncbi.nlm.nih.gov/35257889 Zobrazit plný text záznamu Full Text from ScienceDirect