Effect of probucol on the lipid composition of blood plasma, erythrocyte ghosts and liver membranes in mice
| Autor: | Kamen Koumanov, Albena B. Momchilova-Pankova, Tania Markovska, Tania Neicheva, Recaredo Infante |
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| Rok vydání: | 1990 |
| Předmět: |
Probucol
Acetates Biochemistry Phospholipases A chemistry.chemical_compound Membrane Lipids Mice Phospholipase A2 Blood plasma medicine Animals Phospholipids Triglycerides Acetic Acid biology Cholesterol Catabolism Cell Membrane Erythrocyte Membrane Lipid Metabolism Lipids Phospholipases A2 Membrane Sphingomyelin Phosphodiesterase chemistry Liver biology.protein Microsome Microsomes Liver Cholesterol Esters Sphingomyelin medicine.drug |
| Zdroj: | The International journal of biochemistry. 22(9) |
| ISSN: | 0020-711X |
| Popis: | 1. 1. Probucol treatment of mice (0.6 g/kg) induced a decrease of cholesterol (CH) and total phospholipids (PLs) in blood plasma, erythrocyte ghosts, liver plasma and microsomal membranes. 2. 2. The incorporation of [+14C]acetate in the microsomal lipids of probucol-treated mice was lowered by 23% compared to controls. 3. 3. Probucol administration induced a reduced specific activity of PLs, CH and CH esters, whereas in triacylglycerols it was augmented. 4. 4. Phospholipase A2 and neutral sphingomyelinase activities were not enhanced, indicating that the catabolism of the membrane PL was not elevated. |
| Databáze: | OpenAIRE |
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