Effects of Inadequate Folate Intake on the Onset and Progression of Hypertensive Vascular Injury
| Autor: | Shuhei Ebara, Toshiaki Watanabe, Takuya Matsuo, Takashi Kometani, Takaaki Chikugo, Kumiko Takemori |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Connective tissue hyperplasia Medicine (miscellaneous) Spermatogenesis arrest Blood Pressure Testicular artery Muscle hypertrophy Blood cell Folic Acid Internal medicine medicine.artery Rats Inbred SHR Medicine Animals Folate intake Nutrition and Dietetics business.industry Vascular System Injuries Rats Haematopoiesis Cerebrovascular Disorders Blood pressure Endocrinology medicine.anatomical_structure Hypertension business |
| Zdroj: | Journal of nutritional science and vitaminology. 67(5) |
| ISSN: | 1881-7742 |
| Popis: | We investigated the effects of inadequate folate intake on the onset and progression of hypertensive organ injury. In the present study, 5-wk-old male stroke-prone spontaneously hypertensive rats (SHRSP) were fed with a normal-folate (control; 160-170 μg of folate/100 g diet) or low-folate (8-10 μg of folate/100 g diet) diet until they reached 25 wk of age. After the animals reached 10 wk of age, the bodyweight of the rats in the low-folate group was lower than that of the rats in the control group. Regarding blood pressure, both groups had severe hypertension of ≥230 mmHg at 12 wk of age that was not significantly different between the groups. At 16 wk of age, the low-folate group had a low number of blood cell types. The folate levels in the serum, liver, and kidneys of these rats were significantly lower (p |
| Databáze: | OpenAIRE |
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