Syntheses of Oxazabicycle Library via One-Pot Tandem Reactions
| Autor: | Jiun-Ting Lai, Pei-Shan Shieh, Wei-Hao Huang, Ding-Yah Yang |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Recrystallization (geology)
Molecular Structure Tandem Ethyl acetate Stereoisomerism General Chemistry Bridged Bicyclo Compounds Heterocyclic chemistry.chemical_compound Column chromatography chemistry Cascade reaction Dimedone Oxazines Organometallic Compounds Combinatorial Chemistry Techniques Organic chemistry Ytterbium Methylene Crystallization Isobutyraldehyde |
| Zdroj: | Journal of Combinatorial Chemistry. 10:381-386 |
| ISSN: | 1520-4774 1520-4766 |
| DOI: | 10.1021/cc8000025 |
| Popis: | A practical protocol for the preparation of a parallel solution-phase library of oxazabicycle is reported. Target compounds were obtained in moderate to good yields by a Yb(OTf)3-catalyzed one-pot tandem reaction from various anisidines, aromatic aldehydes, isobutyraldehyde, and 4-hydroxycoumarins/dimedone. Purification of the final products by either recrystallization in ethyl acetate/methylene chloride or column chromatography allowed easy isolation of the 18 components of the array. |
| Databáze: | OpenAIRE |
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