Assessment of Cortisol Response With Low-Dose and High-Dose ACTH in Patients With Chronic Fatigue Syndrome and Healthy Comparison Subjects
| Autor: | Ulrike Ehlert, Renate Peisen, Vera Heitz, Tanja Schad, Th. Schürmeyer, Dominik Hüster, Jens Gaab, Veronika Engert |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Hydrocortisone medicine.medical_treatment Adrenocorticotropic hormone Primary Adrenal Insufficiency Adrenocorticotropic Hormone Arts and Humanities (miscellaneous) Internal medicine medicine Chronic fatigue syndrome Humans Young adult Saliva Applied Psychology Fatigue Syndrome Chronic Dose-Response Relationship Drug business.industry medicine.disease Psychiatry and Mental health Steroid hormone Endocrinology Etiology Female business Glucocorticoid medicine.drug |
| Zdroj: | Psychosomatics. 44:113-119 |
| ISSN: | 0033-3182 |
| DOI: | 10.1176/appi.psy.44.2.113 |
| Popis: | A reduced secretion of cortisol has been proposed as a possible explanation of the symptoms in chronic fatigue syndrome. However, the evidence of hypocortisolism in chronic fatigue syndrome is conflicting. In order to simultaneously assess possible alterations in adrenocortical sensitivity and secretory adrenal reserve, the authors administered both low-dose and high-dose ACTH to a group of 18 chronic fatigue syndrome patients and 18 age- and gender-matched healthy comparison subjects. No response differences for salivary and plasma cortisol were detectable after administration of either low-dose or high-dose ACTH, indicating that primary adrenal insufficiency is unlikely to play a significant role in the etiology of chronic fatigue syndrome. |
| Databáze: | OpenAIRE |
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