Alterations in the extrinsic pathway in hypertriglyceridemia do not cause a ‘procoagulant state': effects of bezafibrate therapy
| Autor: | Augustinus H. M. Smelt, N. H. Van Tilburg, R M Bertina, Ilse Jonkers, Per Morten Sandset, A. van der Laarse, F.H.A.F. de Man |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty Lipoproteins Factor VIIa Fibrinogen Tissue factor chemistry.chemical_compound Tissue factor pathway inhibitor Internal medicine medicine Humans Thrombophilia Antigens Hypolipidemic Agents Hypertriglyceridemia Hemostasis Bezafibrate Factor VII medicine.diagnostic_test business.industry Hematology General Medicine Middle Aged medicine.disease Lipids Blood Coagulation Factors Endocrinology Coagulation chemistry Female Lipid profile business medicine.drug |
| Zdroj: | Blood Coagulation & Fibrinolysis. 12:705-712 |
| ISSN: | 0957-5235 |
| DOI: | 10.1097/00001721-200112000-00013 |
| Popis: | Hypertriglyceridemia (HTG) is an independent risk factor for cardiovascular disease (CVD). Hemostatic variables [factor VII antigen (FVIIag), factor VII coagulant activity (FVIIc), activated factor VII (FVIIa), free and endothelial-associated (EC) tissue factor pathway inhibitor (TFPI) antigen, pre- and post-heparin total TFPI activity, EC-TFPI activity, prothrombin fragment 1 + 2 (F1 + 2), fibrinogen and D-dimer] were compared between 18 HTG patients and 20 controls to investigate whether HTG is associated with alterations in the extrinsic pathway and whether such alterations create a procoagulant state, as expressed by F1 + 2 and D-dimer levels. In addition, the effects of bezafibrate therapy (6 weeks, 400 mg/day) on these variables were studied in 18 HTG patients in a double-blind, placebo-controlled, cross-over study. FVIIag, FVIIc, free TFPI and fibrinogen were significantly higher in HTG patients (by 44, 30, 45 and 31%, respectively; all P < 0.02), while FVIIa, EC-TFPIag and activity, total TFPI activities, F1 + 2 and D-dimer levels were similar in patients and controls. Bezafibrate reduced serum TG and fibrinogen levels (by 62 and 20%, respectively; both P < 0.001), whereas the other hemostatic variables were unaffected. In conclusion, the observed alterations in the extrinsic pathway in HTG are not associated with a procoagulant state. In contrast, the presence of elevated fibrinogen levels in HTG might enhance the risk for CVD. Bezafibrate therapy improved the adverse lipid profile and decreased fibrinogen levels in HTG patients. |
| Databáze: | OpenAIRE |
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